Linked Life Data

20683020

Source:http://linkedlifedata.com/resource/pubmed/id/20683020

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2010-8-4
pubmed:abstractText
BACKGROUND: Calpains (CAPN) are intracellular, non-lysosomal cytoplasmic cysteine endopeptidases and they are expressed ubiquitously. Their endogenous specific inhibitor is calpastatin. When calcium is present, calpastatin and calpain attach to each other, inhibiting the protease. The calpain system plays an important role in many processes including apoptosis, necrosis, ischaemia and exocytosis. The role of calpains in pathogenesis or further tumour progression has been proved in related studies. This study focused on the expression of the enzymes calpain 1, calpain 2 and the inhibitor calpastatin in normal and malignant endometrial tissue. MATERIALS AND METHODS: Immunohistochemical stainings were performed on paraffin slices and staining intensity, percentage of positive cells and international ratio score were evaluated. Results and conclusion: The endometrial carcinoma showed a higher expression of calpastatin than benign endometrial tissue.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1791-7530
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2837-43
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Immunhistochemical analysis for expression of calpain 1, calpain 2 and calpastatin in endometrial cancer.
pubmed:affiliation
Department of Gynecology and Obstretics, Helios Hospital Krefeld, Lutherplatz 40, 47805 Krefeld, Germany. darius.salehin@helios-kliniken.de
pubmed:publicationType
Journal Article