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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
2010-8-16
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pubmed:abstractText |
Synthesis and biological evaluation of jasplakinolide analogs are described. The synthesis of analogs utilized a diastereoselective syn-aldol reaction and an orthoester Claisen rearrangement as key steps. All synthetic analogs were evaluated for their ability to disrupt the actin cytoskeleton. Compounds 2, 3, and 4 essentially displayed similar activity to jasplakinolide.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20678932-10339509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20678932-10671562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20678932-11178844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20678932-12077149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20678932-14507218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20678932-15731859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20678932-16023351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20678932-17488037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20678932-18508272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20678932-20148556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20678932-6452160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20678932-8195116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20678932-9484954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20678932-9790549
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5104-7
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pubmed:dateRevised |
2011-9-29
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pubmed:meshHeading |
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pubmed:year |
2010
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pubmed:articleTitle |
Synthesis and biological evaluation of new jasplakinolide (jaspamide) analogs.
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pubmed:affiliation |
Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA. akghosh@purdue.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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