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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0013682,
umls-concept:C0018787,
umls-concept:C0030054,
umls-concept:C0033268,
umls-concept:C0038250,
umls-concept:C0043240,
umls-concept:C0086418,
umls-concept:C0205463,
umls-concept:C0332161,
umls-concept:C0374711,
umls-concept:C1522564,
umls-concept:C1705181
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pubmed:issue |
1
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|
pubmed:dateCreated |
2010-12-17
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pubmed:abstractText |
the ex vivo expansion of cardiac stem cells from minimally invasive human heart biopsies yields tens of millions of cells within 3-4 weeks, but chromosomal abnormalities were frequently detected in preliminary production runs. Here we attempt to avoid aneuploidy and improve cell quality by expanding human cardiac stem cells in physiological low-oxygen (5% O(2)) conditions, rather than in traditional culture in a general CO(2) incubator (20% O(2)).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
|
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pubmed:month |
Jan
|
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pubmed:issn |
1755-3245
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
89
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
157-65
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pubmed:meshHeading |
pubmed-meshheading:20675298-Adult,
pubmed-meshheading:20675298-Adult Stem Cells,
pubmed-meshheading:20675298-Aneuploidy,
pubmed-meshheading:20675298-Animals,
pubmed-meshheading:20675298-Cell Aging,
pubmed-meshheading:20675298-Cell Differentiation,
pubmed-meshheading:20675298-Cell Proliferation,
pubmed-meshheading:20675298-DNA Damage,
pubmed-meshheading:20675298-Humans,
pubmed-meshheading:20675298-Male,
pubmed-meshheading:20675298-Mice,
pubmed-meshheading:20675298-Mice, SCID,
pubmed-meshheading:20675298-Muscle Development,
pubmed-meshheading:20675298-Myocardial Infarction,
pubmed-meshheading:20675298-Myocardium,
pubmed-meshheading:20675298-Oxidative Stress,
pubmed-meshheading:20675298-Oxygen,
pubmed-meshheading:20675298-Reactive Oxygen Species,
pubmed-meshheading:20675298-Regeneration,
pubmed-meshheading:20675298-Transplantation, Heterologous
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pubmed:year |
2011
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pubmed:articleTitle |
Expansion of human cardiac stem cells in physiological oxygen improves cell production efficiency and potency for myocardial repair.
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pubmed:affiliation |
The Cedars-Sinai Heart Institute, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA. taosheng.li@cshs.org
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, N.I.H., Extramural
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