Linked Life Data

20660387

Source:http://linkedlifedata.com/resource/pubmed/id/20660387

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2010-8-3
pubmed:abstractText
DNA double-strand breaks (DSBs) are critical cellular lesions that can result from ionizing radiation exposure. A marker for DSB formation is the phosphorylated form of the histone H2 variant H2AX (gamma-H2AX). DSBs also attract the damage sensor p53-binding protein 1 (53BP1) to the DSB-containing chromatin, because 53BP1 associates with the DSB-surrounding chromatin. We studied the induction, persistence, and disappearance of radiation-induced gamma-H2AX and 53BP1 foci after the first (131)I therapy of patients with differentiated thyroid carcinoma, a model for protracted, continuous, internal whole-body irradiation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1535-5667
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1318-25
pubmed:meshHeading
pubmed-meshheading:20660387-Adult, pubmed-meshheading:20660387-Aged, pubmed-meshheading:20660387-Algorithms, pubmed-meshheading:20660387-Blood Cells, pubmed-meshheading:20660387-DNA Breaks, Double-Stranded, pubmed-meshheading:20660387-DNA Damage, pubmed-meshheading:20660387-DNA Repair, pubmed-meshheading:20660387-Dose-Response Relationship, Radiation, pubmed-meshheading:20660387-Female, pubmed-meshheading:20660387-Fluorescent Antibody Technique, pubmed-meshheading:20660387-Histones, pubmed-meshheading:20660387-Humans, pubmed-meshheading:20660387-Intracellular Signaling Peptides and Proteins, pubmed-meshheading:20660387-Iodine Radioisotopes, pubmed-meshheading:20660387-Male, pubmed-meshheading:20660387-Middle Aged, pubmed-meshheading:20660387-Thyroid Neoplasms, pubmed-meshheading:20660387-Thyroidectomy, pubmed-meshheading:20660387-Whole-Body Irradiation
pubmed:year
2010
pubmed:articleTitle
In vivo formation of gamma-H2AX and 53BP1 DNA repair foci in blood cells after radioiodine therapy of differentiated thyroid cancer.
pubmed:affiliation
Department of Nuclear Medicine, University of Würzburg, Würzburg, Germany. Lassmann_m@klinik.uni-wuerzburg.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't