Source:http://linkedlifedata.com/resource/pubmed/id/20647061
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2010-12-15
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| pubmed:abstractText |
We determined the probability of individuals having the 'optimal' mitochondrial biogenesis related endurance polygenic profile, and compared the endurance polygenic profile of Israeli (Caucasian) endurance athletes (n = 74), power athletes (n = 81), and non-athletes (n = 240). We computed a mitochondrial biogenesis related 'endurance genotype score' (EGS, scoring from 0 to 100) from the accumulated combination of six polymorphisms in the PPARGC1A-NRF-TFAM pathway. Some of the variant alleles of the polymorphisms studied were so infrequent, that the probability of possessing an 'optimal' EGS (= 100) was 0% in the entire study population. However, the EGS was significantly higher (P<0.001) in endurance athletes (38.9 ± 17.1) compared with controls (30.6 ± 12.4) or power athletes (29.0 ± 11.2). In summary, although the probability of an individual possessing a theoretically 'optimal' genetic background for endurance sports is very low, in general endurance athletes have a polygenic profile that is more suitable for mitochondrial biogenesis.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
1872-8278
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2010 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
11
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
64-9
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| pubmed:meshHeading |
pubmed-meshheading:20647061-Adult,
pubmed-meshheading:20647061-Athletes,
pubmed-meshheading:20647061-Athletic Performance,
pubmed-meshheading:20647061-European Continental Ancestry Group,
pubmed-meshheading:20647061-Female,
pubmed-meshheading:20647061-Gene Frequency,
pubmed-meshheading:20647061-Genotype,
pubmed-meshheading:20647061-Heat-Shock Proteins,
pubmed-meshheading:20647061-Humans,
pubmed-meshheading:20647061-Israel,
pubmed-meshheading:20647061-Male,
pubmed-meshheading:20647061-Middle Aged,
pubmed-meshheading:20647061-Mitochondria,
pubmed-meshheading:20647061-PPAR delta,
pubmed-meshheading:20647061-Physical Endurance,
pubmed-meshheading:20647061-Polymorphism, Genetic,
pubmed-meshheading:20647061-Sports,
pubmed-meshheading:20647061-Transcription Factors,
pubmed-meshheading:20647061-Young Adult
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| pubmed:year |
2011
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| pubmed:articleTitle |
Mitochondrial biogenesis related endurance genotype score and sports performance in athletes.
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| pubmed:affiliation |
Genetics and Molecular Biology Laboratory, Life Sciences Division, The Zinman College of Physical Education and Sport Sciences at Wingate Institute, Israel. eynon@wincol.ac.il
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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