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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-8-16
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pubmed:abstractText |
Our recent work demonstrated that treatment of neuroblastoma with triptolide causes apoptotic cell death in vitro and decreases tumor size in vivo. Triptolide therapy has been associated with reduced expression of Hsp-70, suggesting a mechanism of cell killing involving Hsp-70 inhibition. The principal objective of this study was to investigate the role of Hsp-70 in triptolide-mediated cell death in neuroblastoma.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1095-8673
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
163
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
72-8
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:20638672-Animals,
pubmed-meshheading:20638672-Antineoplastic Agents, Alkylating,
pubmed-meshheading:20638672-Apoptosis,
pubmed-meshheading:20638672-Cell Line, Tumor,
pubmed-meshheading:20638672-Diterpenes,
pubmed-meshheading:20638672-Drug Evaluation, Preclinical,
pubmed-meshheading:20638672-Epoxy Compounds,
pubmed-meshheading:20638672-Gene Silencing,
pubmed-meshheading:20638672-HSP70 Heat-Shock Proteins,
pubmed-meshheading:20638672-Humans,
pubmed-meshheading:20638672-Mice,
pubmed-meshheading:20638672-Neuroblastoma,
pubmed-meshheading:20638672-Phenanthrenes,
pubmed-meshheading:20638672-RNA, Small Interfering
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pubmed:year |
2010
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pubmed:articleTitle |
Role of Hsp-70 in triptolide-mediated cell death of neuroblastoma.
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pubmed:affiliation |
Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA. antonoff@umn.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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