Linked Life Data

20627739

Source:http://linkedlifedata.com/resource/pubmed/id/20627739

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
2011-3-25
pubmed:abstractText
A compact synthesis of 15 new binaphthyl-based dicationic tripeptoids and one biphenyl based dicationic tripeptoid is described. Fourteen of these tripeptoids resulted from variation of the C-2' ether substituent of the binaphthyl unit. An O-iso-butyl ether binaphthyl derivative was found to be the most active against Staphylococcus aureus (MIC 1.95 ?g/mL). The biphenyl analogue also showed good activity against S. aureus (MIC 1.95 ?g/mL). These compounds, however, were less active against four vancomycin-resistant strains of enterococci (VRE) than some of our previously developed compounds that had an O-iso-pentyl ether substituent on the binaphthyl unit and a C-2 L-Leu moiety.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1464-3391
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4793-800
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 2.
pubmed:affiliation
School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't