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rdf:type |
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lifeskim:mentions |
umls-concept:C0001973,
umls-concept:C0004083,
umls-concept:C0031437,
umls-concept:C0035647,
umls-concept:C0205419,
umls-concept:C0314603,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C1274040,
umls-concept:C1412238,
umls-concept:C1552599,
umls-concept:C1704243,
umls-concept:C1704787,
umls-concept:C2603343
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pubmed:issue |
2
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pubmed:dateCreated |
2011-3-4
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pubmed:abstractText |
Genetic variants of the alcohol-metabolizing enzyme ADH4, located on chromosome 4q22-4q23, have been related to alcohol dependence (AD) risk in previous research. The aim of this association study in a large multicenter sample of alcohol-dependent individuals and controls is to confirm ADH4 single nucleotide polymorphism (SNP) and haplotype association with AD and relevant related phenotypes. One thousand, six hundred and twenty-two (1622) inpatient subjects and 1469 control subjects with DSM-IV. AD from four addiction treatment centres were included. Characteristics of AD and related phenotypes including alcohol withdrawal, Cloninger's type I and II and first ages of drinking, regular drinking and AD onset were obtained using standardized structured interviews. After subjects were genotyped for 2 ADH4 polymorphisms, single SNP case-control and haplotype analyses were conducted. Both variants--rs1800759 and rs1042364--and the A-A and C-G haplotypes were significantly related to AD across samples. Furthermore, associations with AD-related phenotypes and subtypes revealed a potential protective influence of this haplotype. This study confirms the significant relationship of ADH4 variants with AD and related phenotypes. While the rs1800759 and rs1042364 A-A haplotype had a potential protective influence on the risk for several AD-related phenotypes, this effect is rather small compared to functional variants of other alcohol or acetaldehyde-metabolizing enzymes like ALDH2*2 or ADH1B*2.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1369-1600
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pubmed:author |
pubmed-author:BondyBrigittaB,
pubmed-author:DebniakTadeuszT,
pubmed-author:FehrChristophC,
pubmed-author:GrzywaczAnnaA,
pubmed-author:KollerGabrieleG,
pubmed-author:PreussUlrich WUW,
pubmed-author:RidingerMonikaM,
pubmed-author:RujescuDanD,
pubmed-author:SamochowiecJerzyJ,
pubmed-author:SoykaMichaelM,
pubmed-author:WodarzNorbertN,
pubmed-author:WurstFriedrich MFM,
pubmed-author:ZillPeterP
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pubmed:copyrightInfo |
© 2010 The Authors. Journal compilation © 2010 Society for the Study of Addiction.
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pubmed:issnType |
Electronic
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
323-33
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pubmed:meshHeading |
pubmed-meshheading:20626721-Adult,
pubmed-meshheading:20626721-Age of Onset,
pubmed-meshheading:20626721-Alcohol Dehydrogenase,
pubmed-meshheading:20626721-Alcohol Withdrawal Delirium,
pubmed-meshheading:20626721-Alcohol Withdrawal Seizures,
pubmed-meshheading:20626721-Alcoholism,
pubmed-meshheading:20626721-Aldehyde Dehydrogenase,
pubmed-meshheading:20626721-Alleles,
pubmed-meshheading:20626721-Case-Control Studies,
pubmed-meshheading:20626721-Female,
pubmed-meshheading:20626721-Gene Frequency,
pubmed-meshheading:20626721-Genetic Association Studies,
pubmed-meshheading:20626721-Genetic Variation,
pubmed-meshheading:20626721-Genotype,
pubmed-meshheading:20626721-Germany,
pubmed-meshheading:20626721-Haplotypes,
pubmed-meshheading:20626721-Humans,
pubmed-meshheading:20626721-Linkage Disequilibrium,
pubmed-meshheading:20626721-Male,
pubmed-meshheading:20626721-Middle Aged,
pubmed-meshheading:20626721-Phenotype,
pubmed-meshheading:20626721-Poland,
pubmed-meshheading:20626721-Polymorphism, Single Nucleotide
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pubmed:year |
2011
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pubmed:articleTitle |
Association of ADH4 genetic variants with alcohol dependence risk and related phenotypes: results from a larger multicenter association study.
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pubmed:affiliation |
Department of Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University, Halle-Wittenberg, Julius-Kühn-Str. 7, D–06112 Halle, Germany. ulrich.preuss@medizin.uni-halle.de
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pubmed:publicationType |
Journal Article,
Multicenter Study
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