Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-8-5
pubmed:abstractText
The response to respiratory syncytial virus (RSV), negative strand ssRNA virus, depends upon the ability to recognize specific pathogen-associated targets. In the current study, the role of TLR7 that recognizes ssRNA was examined. Using TLR7(-/-) mice, we found that the response to RSV infection in the lung was more pathogenic as assessed by significant increases in inflammation and mucus production. Although there appeared to be no effect of TLR7 deficiency on type I IFN, the pathology was associated with an alteration in T cell responses with increases in mucogenic cytokines IL-4, IL-13, and IL-17. Examination of dendritic cells from TLR7(-/-) animals indicated a preferential activation of IL-23 (a Th17-promoting cytokine) and a decrease in IL-12 production. Neutralization of IL-17 in the TLR7(-/-) mice resulted in a significant decrease in the mucogenic response in the lungs of the RSV-infected mice. Thus, without TLR7-mediated responses, an altered immune environment ensued with a significant effect on airway epithelial cell remodeling and goblet cell hyper/metaplasia, leading to increased mucus production.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-10470697, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-11044374, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-11062499, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-11602714, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-11884466, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-12045249, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-12119052, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-12376053, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-12402188, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-12524386, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-12527213, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-12563297, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-12624114, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-12688623, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-14615709, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-14738455, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-14976261, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-15034168, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-15048726, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-15143473, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-15592841, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-15682636, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-15731229, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-15827165, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-16014923, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-16027234, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-16159623, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-16285209, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-16424225, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-16551253, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-16785528, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-16890779, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-16936271, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-17108032, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-17142025, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-17264400, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-17442966, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-17449325, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-17471431, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-17579031, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-17709532, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-18088248, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-18250417, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-18474642, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-18571707, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-18613842, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-18641647, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-18682521, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-18780793, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-19013492, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-19019963, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-19114863, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-19265172, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-19592489, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-19682929, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-2117143, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624950-9987152
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1550-6606
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
185
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2231-9
pubmed:dateRevised
2011-8-16
pubmed:meshHeading
More...