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rdf:type |
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|
lifeskim:mentions |
|
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pubmed:issue |
14
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pubmed:dateCreated |
2010-7-12
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pubmed:abstractText |
A novel series of pyrrole inhibitors of MEK kinase has been developed using structure-based drug design. Optimization of the series led to the identification of potent inhibitors with good pharmaceutical properties.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:copyrightInfo |
2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4156-8
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pubmed:meshHeading |
pubmed-meshheading:20621728-Animals,
pubmed-meshheading:20621728-Crystallography, X-Ray,
pubmed-meshheading:20621728-Drug Design,
pubmed-meshheading:20621728-MAP Kinase Kinase Kinases,
pubmed-meshheading:20621728-Models, Molecular,
pubmed-meshheading:20621728-Molecular Structure,
pubmed-meshheading:20621728-Protein Kinase Inhibitors,
pubmed-meshheading:20621728-Pyrroles,
pubmed-meshheading:20621728-Rats
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pubmed:year |
2010
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|
pubmed:articleTitle |
Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors.
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|
pubmed:affiliation |
Takeda San Diego, 10410 Science Center Drive, San Diego, CA 92121, United States. michael.wallace@takedasd.com
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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