Linked Life Data

20615026

Source:http://linkedlifedata.com/resource/pubmed/id/20615026

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-7-9
pubmed:abstractText
There is considerable interest in developing new methods for in vivo imaging of the complex anatomy of the mammalian cochlea for clinical as well as fundamental studies. In this study, we explored, the feasibility of spectral domain optical coherence tomography (SD-OCT) for 3-D in vivo imaging of the cochlea in mice. The SD-OCT system employed in this study used a broadband light source centered at 1300 nm, and the imaging speed of the system was 47,000 A-scans per second using the InGaAs camera. The system was capable of providing fully processed, high-resolution B-scan images [512 (axial) x 128 (lateral) pixels] at 280 frames per sec. The 3-D imaging acquisition time for a whole cochlea was approximately 0.45 sec. The traditional SD-OCT structural imaging algorithm was used to reconstruct 3-D cochlear morphology. We demonstrated that SD-OCT can be successfully used for in vivo imaging of important morphological features within the mouse cochlea, such as the otic capsule and structures within, including Reissner's membrane, the basilar membrane, tectorial membrane, organ of Corti, and modiolus of the apical and middle turns.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1560-2281
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
036024
pubmed:dateRevised
2011-10-14
pubmed:meshHeading
pubmed:articleTitle
Volumetric in vivo imaging of intracochlear microstructures in mice by high-speed spectral domain optical coherence tomography.
pubmed:affiliation
Oregon Health and Science University, School of Medicine, Department of Biomedical Engineering, Biophotonics and Imaging Laboratory, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural