Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2010-7-30
pubmed:abstractText
The novel cytokine melanoma differentiation associated gene-7 (mda-7) was identified by subtractive hybridization in the mid-1990s as a protein whose expression increased during the induction of terminal differentiation, and that was either not expressed or was present at low levels in tumor cells compared with non-transformed cells. On the basis of conserved structure, chromosomal location and cytokine-like properties, MDA-7, has now been classified as a member of the expanding interleukin (IL)-10 gene family and designated as MDA-7/IL-24. Multiple studies have shown that the expression of MDA-7/IL-24 in a wide variety of tumor cell types, but not in the corresponding equivalent non-transformed cells, causes their growth arrest and ultimately cell death. In addition, MDA-7/IL-24 has been noted to be a radiosensitizing cytokine, which is partly because of the generation of reactive oxygen species and ceramide that cause endoplasmic reticulum stress. Phase I clinical trial data has shown that a recombinant adenovirus expressing MDA-7/IL-24 [Ad.mda-7 (INGN-241)] was safe and had measurable tumoricidal effects in over 40% of patients, which strongly argues that MDA-7/IL-24 may have significant therapeutic value. This review describes what is known about the impact of MDA-7/IL-24 on tumor cell biology and its potential therapeutic applications.
pubmed:grant
http://linkedlifedata.com/resource/pubmed/grant/P01 CA104177-050002, http://linkedlifedata.com/resource/pubmed/grant/P01-CA104177, http://linkedlifedata.com/resource/pubmed/grant/P01-NS031492, http://linkedlifedata.com/resource/pubmed/grant/R01 CA108520-05, http://linkedlifedata.com/resource/pubmed/grant/R01 CA141703-01A2, http://linkedlifedata.com/resource/pubmed/grant/R01 CA150214-01A1, http://linkedlifedata.com/resource/pubmed/grant/R01 DK052825-12, http://linkedlifedata.com/resource/pubmed/grant/R01-CA097318, http://linkedlifedata.com/resource/pubmed/grant/R01-CA098712, http://linkedlifedata.com/resource/pubmed/grant/R01-CA108325, http://linkedlifedata.com/resource/pubmed/grant/R01-CA63753, http://linkedlifedata.com/resource/pubmed/grant/R01-CA77141, http://linkedlifedata.com/resource/pubmed/grant/R01-DK52825
pubmed:commentsCorrections
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pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1473-5741
pubmed:author
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