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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2010-11-2
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pubmed:abstractText |
The peroxisome proliferator-activated receptor-?2 (PPAR?2) participates in the regulation of insulin sensitivity, and has connections to the GH-IGF system and ACTH-adrenal androgen axis. We hypothesized that PPARG Pro12Ala polymorphism leading to decreased receptor activity could contribute to the premature onset of adrenarche (PA).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1663-2826
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 S. Karger AG, Basel.
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pubmed:issnType |
Electronic
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
365-71
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pubmed:meshHeading |
pubmed-meshheading:20606394-Adrenal Glands,
pubmed-meshheading:20606394-Adrenarche,
pubmed-meshheading:20606394-Androgens,
pubmed-meshheading:20606394-Body Mass Index,
pubmed-meshheading:20606394-Child,
pubmed-meshheading:20606394-Cross-Sectional Studies,
pubmed-meshheading:20606394-DNA,
pubmed-meshheading:20606394-Female,
pubmed-meshheading:20606394-Finland,
pubmed-meshheading:20606394-Gene Frequency,
pubmed-meshheading:20606394-Genotype,
pubmed-meshheading:20606394-Glucose Tolerance Test,
pubmed-meshheading:20606394-Growth,
pubmed-meshheading:20606394-Humans,
pubmed-meshheading:20606394-Hyperinsulinism,
pubmed-meshheading:20606394-Insulin Resistance,
pubmed-meshheading:20606394-Insulin-Like Growth Factor I,
pubmed-meshheading:20606394-Male,
pubmed-meshheading:20606394-PPAR gamma,
pubmed-meshheading:20606394-Polymorphism, Genetic,
pubmed-meshheading:20606394-Puberty, Precocious,
pubmed-meshheading:20606394-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2010
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pubmed:articleTitle |
Polymorphism Pro12Ala of PPARG in prepubertal children with premature adrenarche and its association with growth in healthy children.
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pubmed:affiliation |
Department of Pediatrics, Kuopio University Hospital, University of Eastern Finland, Kuopio, Finland. saila.lappalainen@uef.fi
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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