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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-7-27
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pubmed:abstractText |
Th cells that produce IL-17 (Th17 cells) are a distinct subset of Th cells implicated in several autoimmune diseases. Although CD28-B7 interaction has been shown to be involved in Th17 differentiation in vitro, the role of CTLA-4 in controlling Th17 development is completely unknown. We report in this paper that blocking the CTLA-4-B7 interaction potentiates Th17 cell differentiation in vitro and in vivo. Furthermore, blocking CTLA-4-B7 interaction in vivo confers the susceptibility of experimental autoimmune myocarditis to CD28(-/-) mice or increases the severity of experimental autoimmune myocarditis in wild-type mice. The enhanced disease susceptibility is mediated by heightened Th17 responses. With these results, we are the first to demonstrate that CTLA-4-B7 interaction inhibits Th17 differentiation in vitro and in vivo and suppresses Th17-mediated autoimmunity.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20601598-10903737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20601598-11244036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20601598-12087419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20601598-12368911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20601598-14575153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20601598-15585834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20601598-16200068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20601598-16880257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20601598-17227914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20601598-17375096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20601598-18250481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20601598-18779348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20601598-19132915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20601598-7481803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20601598-7584144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20601598-8228811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20601598-8676074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20601598-9143690,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20601598-9430233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20601598-9892625
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Ctla4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-17
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1550-6606
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
185
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1375-8
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20601598-Amino Acid Sequence,
pubmed-meshheading:20601598-Animals,
pubmed-meshheading:20601598-Antigens, CD,
pubmed-meshheading:20601598-Antigens, CD28,
pubmed-meshheading:20601598-Antigens, CD80,
pubmed-meshheading:20601598-Autoimmune Diseases,
pubmed-meshheading:20601598-CTLA-4 Antigen,
pubmed-meshheading:20601598-Cell Differentiation,
pubmed-meshheading:20601598-Cells, Cultured,
pubmed-meshheading:20601598-Down-Regulation,
pubmed-meshheading:20601598-Genetic Predisposition to Disease,
pubmed-meshheading:20601598-Growth Inhibitors,
pubmed-meshheading:20601598-Interleukin-17,
pubmed-meshheading:20601598-Mice,
pubmed-meshheading:20601598-Mice, Inbred BALB C,
pubmed-meshheading:20601598-Mice, Inbred C57BL,
pubmed-meshheading:20601598-Mice, Knockout,
pubmed-meshheading:20601598-Molecular Sequence Data,
pubmed-meshheading:20601598-Myocarditis,
pubmed-meshheading:20601598-T-Lymphocytes, Helper-Inducer
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pubmed:year |
2010
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pubmed:articleTitle |
Cutting edge: CTLA-4--B7 interaction suppresses Th17 cell differentiation.
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pubmed:affiliation |
Laboratory of Molecular Cancer Biology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People's Republic of China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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