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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2010-9-20
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pubmed:abstractText |
In a genome wide association study consisting of 592 German multiple sclerosis (MS) patients and 825 controls we were able to replicate the association of the HLA region with MS independently of previous case control studies. No SNPs outside the HLA region reached a genome wide level of significance. Nevertheless, we found suggestive evidence for an association of MS with variants in two new genes, the VAV2 gene and the gene for ZNF433.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1872-8421
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pubmed:author |
pubmed-author:BetteckenThomasT,
pubmed-author:CepokSabineS,
pubmed-author:HemmerBernhardB,
pubmed-author:HolsboerFlorianF,
pubmed-author:IsingMarcusM,
pubmed-author:KnopMatthiasM,
pubmed-author:KronerAntjeA,
pubmed-author:Müller-MyhsokBertramB,
pubmed-author:Müller-SarnowskiFelixF,
pubmed-author:NischwitzSandraS,
pubmed-author:PfisterHildegardH,
pubmed-author:RieckmannPeterP,
pubmed-author:RoeskeDarinaD,
pubmed-author:UhrManfredM,
pubmed-author:WeberFrankF,
pubmed-author:WolfChristianeC
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier B.V. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
8
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pubmed:volume |
227
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
162-6
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pubmed:meshHeading |
pubmed-meshheading:20598377-Adolescent,
pubmed-meshheading:20598377-Adult,
pubmed-meshheading:20598377-Aged,
pubmed-meshheading:20598377-Case-Control Studies,
pubmed-meshheading:20598377-Female,
pubmed-meshheading:20598377-Genetic Predisposition to Disease,
pubmed-meshheading:20598377-Genome-Wide Association Study,
pubmed-meshheading:20598377-HLA Antigens,
pubmed-meshheading:20598377-Humans,
pubmed-meshheading:20598377-Male,
pubmed-meshheading:20598377-Middle Aged,
pubmed-meshheading:20598377-Multiple Sclerosis,
pubmed-meshheading:20598377-Polymorphism, Single Nucleotide,
pubmed-meshheading:20598377-Proto-Oncogene Proteins c-vav,
pubmed-meshheading:20598377-Repressor Proteins,
pubmed-meshheading:20598377-Young Adult,
pubmed-meshheading:20598377-Zinc Fingers
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pubmed:year |
2010
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pubmed:articleTitle |
Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis.
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pubmed:affiliation |
Max Planck Institute of Psychiatry, 80804 Munich, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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