Linked Life Data

20596994

Source:http://linkedlifedata.com/resource/pubmed/id/20596994

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-7-2
pubmed:abstractText
Histologic grade is a significant predictor of outcome in salivary gland carcinomas. However, the sheer variety of tumor type and the rarity of these tumors pose challenges to devising highly predictive grading schemes. As our knowledge base has evolved, it is clear that carcinoma ex pleomorphic adenoma is not automatically a high grade tumor as is traditionally suggested. These tumors should be further qualified as to type/grade of carcinoma and extent, since intracapsular and minimally invasive carcinomas ex pleomorphic adenoma behave favorably. The two carcinoma types for which grading schemes are common include adenoid cystic carcinoma and mucoepidermoid carcinoma. Adenoid cystic carcinomas are graded based solely on pattern with solid components portending a worse prognosis. Occasionally, adenoid cystic carcinomas may undergo transformation to pleomorphic high grade carcinomas. This feature confers a high propensity for lymph node metastasis and should thus be reported to alert the clinical team. Mucoepidermoid carcinomas are graded in a three tier fashion based on a constellation of features including cystic component, border, mitoses, anaplasia, and perineural invasion among others. All grading schemes are somewhat cumbersome, intimidating and occasionally ambiguous, but evidence suggests that using a scheme consistently shows greater reproducibility than using an intuitive approach. The intermediate grade category demonstrates the most variability between grading systems and thus the most controversy in management. In the AFIP system intermediate grade tumors cluster with high grade tumors, while in the Brandwein system, they cluster with low grade tumors.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20596994-10037280, http://linkedlifedata.com/resource/pubmed/commentcorrection/20596994-11431714, http://linkedlifedata.com/resource/pubmed/commentcorrection/20596994-12484654, http://linkedlifedata.com/resource/pubmed/commentcorrection/20596994-13106826, http://linkedlifedata.com/resource/pubmed/commentcorrection/20596994-1334380, http://linkedlifedata.com/resource/pubmed/commentcorrection/20596994-13536351, http://linkedlifedata.com/resource/pubmed/commentcorrection/20596994-16003616, http://linkedlifedata.com/resource/pubmed/commentcorrection/20596994-16274796, http://linkedlifedata.com/resource/pubmed/commentcorrection/20596994-17858687, http://linkedlifedata.com/resource/pubmed/commentcorrection/20596994-18030166, http://linkedlifedata.com/resource/pubmed/commentcorrection/20596994-18059225, http://linkedlifedata.com/resource/pubmed/commentcorrection/20596994-18720358, http://linkedlifedata.com/resource/pubmed/commentcorrection/20596994-1985714, http://linkedlifedata.com/resource/pubmed/commentcorrection/20596994-208752, http://linkedlifedata.com/resource/pubmed/commentcorrection/20596994-2221741, http://linkedlifedata.com/resource/pubmed/commentcorrection/20596994-6088017, http://linkedlifedata.com/resource/pubmed/commentcorrection/20596994-9158708, http://linkedlifedata.com/resource/pubmed/commentcorrection/20596994-9269302, http://linkedlifedata.com/resource/pubmed/commentcorrection/20596994-9529011
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1936-0568
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
69-77
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
An update on grading of salivary gland carcinomas.
pubmed:affiliation
Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, A616.3 PUH, 200 Lothrop St, Pittsburgh, PA 15213, USA. seethalarr@upmc.edu
pubmed:publicationType
Journal Article, Review