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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-6-30
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pubmed:abstractText |
Although clarithromycin (CLR) is one of the most commonly recommended component drugs of Helicobacter pylori eradication regimens, the prevalence of CLR-resistant H. pylori has been increasing. It is well known that CLR resistance is associated with point mutations in 23S rRNA, but an active multidrug efflux mechanism of H. pylori may also play a role in its drug resistance. At least four gene clusters have been identified as efflux pump systems in H. pylori and the present study was designed to investigate their role in the CLR resistance of clinical isolates of H. pylori.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Clarithromycin,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Ribosomal,
http://linkedlifedata.com/resource/pubmed/chemical/Dipeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Ribosomal, 23S,
http://linkedlifedata.com/resource/pubmed/chemical/phenylalanine arginine...
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1440-1746
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
25 Suppl 1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
S75-9
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pubmed:meshHeading |
pubmed-meshheading:20586871-Aged,
pubmed-meshheading:20586871-Bacterial Proteins,
pubmed-meshheading:20586871-Clarithromycin,
pubmed-meshheading:20586871-DNA, Ribosomal,
pubmed-meshheading:20586871-Dipeptides,
pubmed-meshheading:20586871-Drug Resistance, Bacterial,
pubmed-meshheading:20586871-Female,
pubmed-meshheading:20586871-Genes, rRNA,
pubmed-meshheading:20586871-Helicobacter Infections,
pubmed-meshheading:20586871-Helicobacter pylori,
pubmed-meshheading:20586871-Humans,
pubmed-meshheading:20586871-Male,
pubmed-meshheading:20586871-Membrane Transport Proteins,
pubmed-meshheading:20586871-Microbial Sensitivity Tests,
pubmed-meshheading:20586871-Middle Aged,
pubmed-meshheading:20586871-Models, Molecular,
pubmed-meshheading:20586871-Point Mutation,
pubmed-meshheading:20586871-Protein Conformation,
pubmed-meshheading:20586871-RNA, Bacterial,
pubmed-meshheading:20586871-RNA, Ribosomal, 23S
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pubmed:year |
2010
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pubmed:articleTitle |
Contribution of efflux pumps to clarithromycin resistance in Helicobacter pylori.
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pubmed:affiliation |
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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