Source:http://linkedlifedata.com/resource/pubmed/id/20581807
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
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| pubmed:dateCreated |
2010-10-4
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| pubmed:abstractText |
Medullary carcinomas have a better prognosis than other grade 3 mammary carcinomas, but they typically show basal-like biological features, which are associated with a poor prognosis. In this study we examined the associations and prognostic relevance of medullary histological features in a series of 165 invasive carcinomas with a basal-like phenotype: triple-negative (oestrogen receptor, progesterone receptor, HER2) and expressing at least one basal marker (CK5/6, CK14, CK17 or EGFR). The following histological features were associated with each other: prominent inflammation, anastomosing sheets, absence of fibrosis, absence of infiltrative margin and absence of gland formation. Prominent inflammation and anastomosing sheets in at least 30% of the tumour were associated with a better prognosis on univariate analysis. The combination of these two features (a simplified definition of medullary-like type) was present in 17% of tumours and was an independent prognostic factor on multivariate analysis. This simplified definition had good inter-observer reproducibility (?=0.61) and is worthy of more detailed assessment in an unselected group of mammary carcinomas. A fibrotic focus was present in 36% of carcinomas. Only 3% of tumours with a fibrotic focus had features of medullary-like carcinomas. Fibrotic focus of greater than 30% of the tumour was associated with a poor prognosis. This study emphasizes the heterogeneity of morphology and behaviour of triple-negative basal-like carcinomas.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Keratin-14,
http://linkedlifedata.com/resource/pubmed/chemical/Keratin-17,
http://linkedlifedata.com/resource/pubmed/chemical/Keratin-5,
http://linkedlifedata.com/resource/pubmed/chemical/Keratin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Estrogen,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Progesterone,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
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| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
1530-0285
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
23
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1357-63
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| pubmed:meshHeading |
pubmed-meshheading:20581807-Aged,
pubmed-meshheading:20581807-Breast Neoplasms,
pubmed-meshheading:20581807-Carcinoma, Medullary,
pubmed-meshheading:20581807-Female,
pubmed-meshheading:20581807-Genes, erbB-2,
pubmed-meshheading:20581807-Humans,
pubmed-meshheading:20581807-Immunophenotyping,
pubmed-meshheading:20581807-Kaplan-Meier Estimate,
pubmed-meshheading:20581807-Keratin-14,
pubmed-meshheading:20581807-Keratin-17,
pubmed-meshheading:20581807-Keratin-5,
pubmed-meshheading:20581807-Keratin-6,
pubmed-meshheading:20581807-Middle Aged,
pubmed-meshheading:20581807-Prognosis,
pubmed-meshheading:20581807-Receptor, Epidermal Growth Factor,
pubmed-meshheading:20581807-Receptors, Estrogen,
pubmed-meshheading:20581807-Receptors, Progesterone,
pubmed-meshheading:20581807-Tumor Markers, Biological
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| pubmed:year |
2010
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| pubmed:articleTitle |
Histological features of medullary carcinoma and prognosis in triple-negative basal-like carcinomas of the breast.
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| pubmed:affiliation |
Department of Histopathology, Nottingham University Hospitals, Nottingham, UK.
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| pubmed:publicationType |
Journal Article
|