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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2010-8-19
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pubmed:abstractText |
Factors released by perivascular adipose tissue (PVAT) disrupt coronary endothelial function via phosphorylation of endothelial NO synthase by protein kinase C (PKC)-beta. However, our understanding of how PVAT potentially contributes to coronary disease as a complication of obesity/metabolic syndrome (MetS) remains limited. The current study investigated whether PVAT-derived leptin impairs coronary vascular function via PKC-beta in MetS.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576943-11001066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576943-12460094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576943-14581396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576943-14715497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576943-15653761,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576943-15749744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576943-15894577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576943-16195477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576943-16311216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576943-16336196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576943-16741160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576943-16905596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576943-17384455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576943-17662969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576943-17878891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576943-17884060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576943-18375717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576943-18390821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576943-18574744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576943-18843191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576943-18949545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576943-19229071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576943-19342450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576943-19482966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576943-19571581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576943-19724019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576943-20044440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576943-9083520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20576943-9887164
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1524-4636
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1711-7
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:20576943-Adipose Tissue,
pubmed-meshheading:20576943-Animals,
pubmed-meshheading:20576943-Coronary Vessels,
pubmed-meshheading:20576943-Disease Models, Animal,
pubmed-meshheading:20576943-Dose-Response Relationship, Drug,
pubmed-meshheading:20576943-Endothelium, Vascular,
pubmed-meshheading:20576943-Female,
pubmed-meshheading:20576943-Leptin,
pubmed-meshheading:20576943-Male,
pubmed-meshheading:20576943-Metabolic Syndrome X,
pubmed-meshheading:20576943-Pericardium,
pubmed-meshheading:20576943-Phenotype,
pubmed-meshheading:20576943-Protein Kinase C,
pubmed-meshheading:20576943-Protein Kinase Inhibitors,
pubmed-meshheading:20576943-Receptors, Leptin,
pubmed-meshheading:20576943-Signal Transduction,
pubmed-meshheading:20576943-Swine,
pubmed-meshheading:20576943-Swine, Miniature,
pubmed-meshheading:20576943-Up-Regulation,
pubmed-meshheading:20576943-Vasodilation,
pubmed-meshheading:20576943-Vasodilator Agents
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pubmed:year |
2010
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pubmed:articleTitle |
Epicardial perivascular adipose-derived leptin exacerbates coronary endothelial dysfunction in metabolic syndrome via a protein kinase C-beta pathway.
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pubmed:affiliation |
Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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