|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2010-12-14
|
|
pubmed:abstractText |
Ivermectin is an antiparasitic drug frequently administered to humans. It has a limited brain exposure that is attributed to the efflux activity of ABCB1/Abcb1. ABCG2/Abcg2 is also a major transporter present in most pharmacologically important barriers. However, interaction of ivermectin with Abcg2 shows species specificity and in many studies was confounded by the masking effect of ABCB1/Abcb1. In this study using cellular and membrane assays we show that ivermectin displays a high-affinity interaction with human ABCG2 with IC(50) values in the 1-1.5? µM range. This interaction may have implications in human ABCG2-mediated drug-drug interactions of ivermectin.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
1520-6017
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright © 2010 Wiley-Liss, Inc. and the American Pharmacists Association
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
100
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
94-7
|
|
pubmed:meshHeading |
pubmed-meshheading:20574995-ATP-Binding Cassette Transporters,
pubmed-meshheading:20574995-Antiparasitic Agents,
pubmed-meshheading:20574995-Biological Transport, Active,
pubmed-meshheading:20574995-Cell Line,
pubmed-meshheading:20574995-Cell Membrane,
pubmed-meshheading:20574995-Enzyme Inhibitors,
pubmed-meshheading:20574995-Estrone,
pubmed-meshheading:20574995-Humans,
pubmed-meshheading:20574995-Ivermectin,
pubmed-meshheading:20574995-Kinetics,
pubmed-meshheading:20574995-Neoplasm Proteins
|
|
pubmed:year |
2011
|
|
pubmed:articleTitle |
Ivermectin interacts with human ABCG2.
|
|
pubmed:affiliation |
Solvo Biotechnology, Budaörs, Hungary.
|
|
pubmed:publicationType |
Letter,
Research Support, Non-U.S. Gov't
|
