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pubmed-article:20568785pubmed:abstractTextSeven proanthocyanidins (2-8) together with epicatechin (1) were isolated from the EtOH extract of the leaves of Machilus philippinensis. Of these, machiphilitannins A (7) and B (8) are new natural products, with respective IC(50) values of 31.3 (7) and 18.4 microM (8) against alpha-glucosidase type IV from Bacillus stearothermophilus. Their structures were elucidated mainly on the basis of CD and 2D NMR analyses. In addition, aesculitannin B (2) showed inhibitory activity against alpha-glucosidase with an IC(50) value of 3.5 microM. This work demonstrates for the first time that the purified proanthocyanidins possess inhibitory activity against alpha-glucosidase type IV.lld:pubmed
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pubmed-article:20568785pubmed:authorpubmed-author:LeeShoei-Shen...lld:pubmed
pubmed-article:20568785pubmed:authorpubmed-author:LinHsiao-Chin...lld:pubmed
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pubmed-article:20568785pubmed:year2010lld:pubmed
pubmed-article:20568785pubmed:articleTitleProanthocyanidins from the leaves of Machilus philippinensis.lld:pubmed
pubmed-article:20568785pubmed:affiliationSchool of Pharmacy, College of Medicine, National Taiwan University, 1, Sec. 1, Jen-Ai Rd, Taipei 10051, Taiwan, Republic of China.lld:pubmed
pubmed-article:20568785pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20568785pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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