Linked Life Data

20568785

Source:http://linkedlifedata.com/resource/pubmed/id/20568785

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2010-8-27
pubmed:abstractText
Seven proanthocyanidins (2-8) together with epicatechin (1) were isolated from the EtOH extract of the leaves of Machilus philippinensis. Of these, machiphilitannins A (7) and B (8) are new natural products, with respective IC(50) values of 31.3 (7) and 18.4 microM (8) against alpha-glucosidase type IV from Bacillus stearothermophilus. Their structures were elucidated mainly on the basis of CD and 2D NMR analyses. In addition, aesculitannin B (2) showed inhibitory activity against alpha-glucosidase with an IC(50) value of 3.5 microM. This work demonstrates for the first time that the purified proanthocyanidins possess inhibitory activity against alpha-glucosidase type IV.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1520-6025
pubmed:author
pubmed:issnType
Electronic
pubmed:day
27
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1375-80
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Proanthocyanidins from the leaves of Machilus philippinensis.
pubmed:affiliation
School of Pharmacy, College of Medicine, National Taiwan University, 1, Sec. 1, Jen-Ai Rd, Taipei 10051, Taiwan, Republic of China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't