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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0025932,
umls-concept:C0027651,
umls-concept:C0079427,
umls-concept:C0185117,
umls-concept:C0522537,
umls-concept:C1325410,
umls-concept:C1427926,
umls-concept:C1822888,
umls-concept:C2252854,
umls-concept:C2349975,
umls-concept:C2911684
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pubmed:issue |
14
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pubmed:dateCreated |
2010-8-30
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pubmed:abstractText |
Intermittent androgen deprivation therapy (IADT) was developed to improve the quality of life and retard prostate cancer progression to castration resistance. IADT involves regrowth of the tumor during the off cycle upon testosterone recovery. Our previous studies showed that testosterone is more potent than dihydrotestosterone (DHT) in the induction of a subset of androgen-responsive genes during rat prostate regrowth. However, it is not clear if the same phenomenon would occur during androgen-induced regrowth of prostate tumors. Understanding the differences between testosterone and DHT in inducing androgen-responsive genes during prostate tumor regrowth may provide new insight for improving IADT.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564326-11062374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564326-11444528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564326-11867260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564326-12773232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564326-12907652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564326-15065091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564326-15368351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564326-15538746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564326-16372330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564326-16600727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564326-16818707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564326-17699749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564326-17873910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564326-19676093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564326-19676094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564326-2298157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564326-2429759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564326-7682149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564326-7776971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564326-7979239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564326-8146426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564326-8809195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564326-8911533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564326-9048585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564326-9134606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564326-9371789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20564326-9854195
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Androgens,
http://linkedlifedata.com/resource/pubmed/chemical/Azasteroids,
http://linkedlifedata.com/resource/pubmed/chemical/Cholestenone 5 alpha-Reductase,
http://linkedlifedata.com/resource/pubmed/chemical/Dihydrotestosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/FESTA protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Finasteride,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Prostate-Specific Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Testosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/dutasteride
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1097-0045
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pubmed:author |
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pubmed:copyrightInfo |
(c) 2010 Wiley-Liss, Inc.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1575-85
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pubmed:dateRevised |
2011-7-28
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pubmed:meshHeading |
pubmed-meshheading:20564326-Humans,
pubmed-meshheading:20564326-Animals,
pubmed-meshheading:20564326-Mice,
pubmed-meshheading:20564326-Androgens,
pubmed-meshheading:20564326-Testosterone,
pubmed-meshheading:20564326-Prostatic Neoplasms,
pubmed-meshheading:20564326-Male,
pubmed-meshheading:20564326-Enzyme Inhibitors,
pubmed-meshheading:20564326-Cell Division,
pubmed-meshheading:20564326-Neoplasm Transplantation,
pubmed-meshheading:20564326-Dihydrotestosterone,
pubmed-meshheading:20564326-Transplantation, Heterologous,
pubmed-meshheading:20564326-Orchiectomy,
pubmed-meshheading:20564326-Nuclear Proteins,
pubmed-meshheading:20564326-Mice, Nude,
pubmed-meshheading:20564326-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:20564326-Azasteroids,
pubmed-meshheading:20564326-Prostate-Specific Antigen
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