rdf:type |
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0104998,
umls-concept:C0185117,
umls-concept:C0205174,
umls-concept:C0301872,
umls-concept:C1705431,
umls-concept:C2239176,
umls-concept:C2349975,
umls-concept:C2698599,
umls-concept:C2911684
|
pubmed:issue |
4
|
pubmed:dateCreated |
2011-3-14
|
pubmed:abstractText |
Costimulatory signals are essential for T-cell activation and hence play a very important role in antitumor immunity. B7 and 4-1BBL which belongs to tumor necrosis factor (TNF) family provide costimulatory interaction for T-cell activation and function. This study investigated the role of B7 and 4-1BBL in the amplification of tumor immunity by transduction of the B7-1, B7-2 and 4-1BBL into mouse hepatocellular carcinoma cell line H22.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
1432-1335
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:volume |
137
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
695-703
|
pubmed:meshHeading |
pubmed-meshheading:20563597-4-1BB Ligand,
pubmed-meshheading:20563597-Animals,
pubmed-meshheading:20563597-Antigens, CD80,
pubmed-meshheading:20563597-Antigens, CD86,
pubmed-meshheading:20563597-Apoptosis,
pubmed-meshheading:20563597-Carcinoma, Hepatocellular,
pubmed-meshheading:20563597-Cell Line, Tumor,
pubmed-meshheading:20563597-Interferon-gamma,
pubmed-meshheading:20563597-Interleukin-2,
pubmed-meshheading:20563597-Liver Neoplasms,
pubmed-meshheading:20563597-Mice,
pubmed-meshheading:20563597-Mice, Inbred BALB C,
pubmed-meshheading:20563597-NF-kappa B,
pubmed-meshheading:20563597-Phenotype,
pubmed-meshheading:20563597-T-Lymphocytes, Cytotoxic
|
pubmed:year |
2011
|
pubmed:articleTitle |
Triple expression of B7-1, B7-2 and 4-1BBL enhanced antitumor immune response against mouse H22 hepatocellular carcinoma.
|
pubmed:affiliation |
Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|