Linked Life Data

20550548

Source:http://linkedlifedata.com/resource/pubmed/id/20550548

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-7-26
pubmed:abstractText
Natural killer (NK) cells are critical to the immune response to viral infections. Their functions are controlled by receptors for major histocompatibility complex (MHC) class I, including NKG2A and killer-cell immunoglobulin-like receptors (KIR). In order to evaluate the role of MHC class I receptors in the immune response to hepatitis C virus infection we have studied patients with chronic HCV infection by multi-parameter flow cytometry directly ex vivo. This has permitted evaluation of combinatorial expression of activating and inhibitory receptors on single NK cells. Individuals with chronic HCV infection had fewer CD56(dim) NK cells than healthy controls (4.9 +/- 3.4% versus 9.0 +/- 5.9%, P < 0.05). Expression levels of the inhibitory receptor NKG2A was up-regulated on NK cells from individuals with chronic hepatitis C virus (HCV) (NKG2A mean fluorescence intensity 5692 +/- 2032 versus 4525 +/- 1646, P < 0.05). Twelve individuals were treated with pegylated interferon and ribavirin. This resulted in a down-regulation of NKG2A expression on CD56(dim) NK cells. Individuals with a sustained virological response (SVR) had greater numbers of NKG2A-positive, KIR-negative NK cells than those without SVR (27.6 +/- 9.6% NK cells versus 17.6 +/- 5.7, P < 0.02). Our data show that NKG2A expression is dysregulated in chronic HCV infection and that NKG2A-positive NK cells are associated with a beneficial response to pegylated interferon and ribavirin therapy.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-10358757, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-10438977, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-11207248, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-11244035, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-11449378, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-11859120, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-11861603, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-12076868, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-12217606, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-12412456, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-14764669, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-15297676, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-15528315, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-15653307, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-15681828, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-16160163, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-16322112, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-16434388, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-16496327, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-16893656, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-17100887, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-17273991, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-18289678, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-18372499, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-18583565, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-18593587, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-19118515, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-19136945, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-19470388, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-19596474, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-19637199, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-2137855, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-2159050, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-8282480, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-8340759, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-8376937, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-9328121, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-9430220, http://linkedlifedata.com/resource/pubmed/commentcorrection/20550548-9486650
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD56, http://linkedlifedata.com/resource/pubmed/chemical/Antiviral Agents, http://linkedlifedata.com/resource/pubmed/chemical/HLA Antigens, http://linkedlifedata.com/resource/pubmed/chemical/Interferon-alpha, http://linkedlifedata.com/resource/pubmed/chemical/KLRC1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/KLRK1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/NCR1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/NCR3 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/NK Cell Lectin-Like Receptor..., http://linkedlifedata.com/resource/pubmed/chemical/NK Cell Lectin-Like Receptor..., http://linkedlifedata.com/resource/pubmed/chemical/Natural Cytotoxicity Triggering..., http://linkedlifedata.com/resource/pubmed/chemical/Natural Cytotoxicity Triggering..., http://linkedlifedata.com/resource/pubmed/chemical/Polyethylene Glycols, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, KIR, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, KIR2DL1, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, KIR2DL3, http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Ribavirin, http://linkedlifedata.com/resource/pubmed/chemical/interferon alfa-2a, http://linkedlifedata.com/resource/pubmed/chemical/peginterferon alfa-2a
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1365-2249
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
161
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
306-14
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
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