Linked Life Data

2054983

Source:http://linkedlifedata.com/resource/pubmed/id/2054983

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1991-8-1
pubmed:abstractText
A clinico-pathological study of a 39-year-old female with Juvenile parkinsonism was carried out. Although the clinical manifestations were consistent with parkinsonism, the pathological findings were significantly different. Pathological examination showed the lesion to be localized to the substantia nigra, the number of neurons to be abnormally low, the proportion of melanin-containing cells to be reduced, and a large number of immature cells to be present. No neuronal degeneration associated with gliosis or release of melanin granules, such as seen in Parkinson's disease, was observed. Neuropathological studies, including cytometry and comparison against normal controls in the distribution of melanin granules, suggested hypoplasia and poor neuronal maturation of the substantia nigra. Since neuromelanin is thought to be the result of normal dopamine metabolism, reduction of melanin-containing cells in this case suggests inadequate or abnormal dopamine metabolism. Thus, the clinical manifestation of parkinsonism in this case seems to be related to the small number of melanin-containing cells which implies the dopamine deficiency state.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0722-5091
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
91-7
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:articleTitle
Juvenile parkinsonism: a case with first clinical manifestation at the age of six years and with neuropathological findings suggesting a new pathogenesis.
pubmed:affiliation
Department of Neurology, Tokyo Metropolitan Matsuzawa Hospital, Japan.
pubmed:publicationType
Journal Article, Case Reports