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rdf:type |
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lifeskim:mentions |
umls-concept:C0085862,
umls-concept:C0086982,
umls-concept:C0164786,
umls-concept:C0243077,
umls-concept:C0449445,
umls-concept:C0812228,
umls-concept:C1280500,
umls-concept:C1299583,
umls-concept:C1549571,
umls-concept:C1608386,
umls-concept:C1880022,
umls-concept:C1883254,
umls-concept:C2003903
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pubmed:dateCreated |
2010-7-2
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pubmed:abstractText |
Signal transduction processes mediated by phosphatidyl inositol phosphates affect a broad range of cellular processes such as cell cycle progression, migration and cell survival. The protein kinase AKT is one of the major effectors in this signaling network. Chronic AKT activation contributes to oncogenic transformation and tumor development. Therefore, analogs of phosphatidyl inositol phosphates (PIAs) were designed as new small drugs to block AKT activity for cancer treatment. Here we characterize the biological effects of the PIAs SH-5 and SH-6 in colorectal cancer cell lines.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546605-10579926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546605-11526487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546605-11756242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546605-11781306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546605-12094235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546605-12115344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546605-12526803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546605-12553797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546605-12963707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546605-14502432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546605-15016963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546605-15087394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546605-15616196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546605-16051184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546605-16176576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546605-16219694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546605-16341064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546605-16376301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546605-16546986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546605-16704377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546605-16908667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546605-17008526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546605-17041247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546605-17167784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546605-17276916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546605-17534152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546605-17631503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546605-9655291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20546605-9885575
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2407
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
287
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pubmed:dateRevised |
2010-9-30
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pubmed:meshHeading |
pubmed-meshheading:20546605-Antineoplastic Agents,
pubmed-meshheading:20546605-Apoptosis,
pubmed-meshheading:20546605-Blotting, Western,
pubmed-meshheading:20546605-Cell Separation,
pubmed-meshheading:20546605-Cell Shape,
pubmed-meshheading:20546605-Cell Survival,
pubmed-meshheading:20546605-Colorectal Neoplasms,
pubmed-meshheading:20546605-Computational Biology,
pubmed-meshheading:20546605-Cytokinesis,
pubmed-meshheading:20546605-Enzyme Activation,
pubmed-meshheading:20546605-Flow Cytometry,
pubmed-meshheading:20546605-Gene Expression Profiling,
pubmed-meshheading:20546605-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:20546605-HCT116 Cells,
pubmed-meshheading:20546605-HT29 Cells,
pubmed-meshheading:20546605-Humans,
pubmed-meshheading:20546605-Inositol Phosphates,
pubmed-meshheading:20546605-Microscopy, Confocal,
pubmed-meshheading:20546605-Microscopy, Video,
pubmed-meshheading:20546605-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:20546605-Phosphatidylinositols,
pubmed-meshheading:20546605-Phosphorylation,
pubmed-meshheading:20546605-Protein Kinase Inhibitors,
pubmed-meshheading:20546605-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:20546605-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20546605-Signal Transduction,
pubmed-meshheading:20546605-Time Factors
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pubmed:year |
2010
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pubmed:articleTitle |
Characterization of AKT independent effects of the synthetic AKT inhibitors SH-5 and SH-6 using an integrated approach combining transcriptomic profiling and signaling pathway perturbations.
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pubmed:affiliation |
Laboratory of Molecular Tumor Pathology, Institute of Pathology, Charité, Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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