|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
11
|
|
pubmed:dateCreated |
2010-10-28
|
|
pubmed:abstractText |
Complement factor H (Cfh) is a key regulator of the alternative complement pathway. A Cfh variant (Y402H) increases the risk for AMD. The purpose of this study was to develop a pathophysiologically relevant animal model of AMD based on this genetic risk factor.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
1552-5783
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
51
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
5878-87
|
|
pubmed:meshHeading |
pubmed-meshheading:20538999-Animals,
pubmed-meshheading:20538999-Blotting, Western,
pubmed-meshheading:20538999-Chimera,
pubmed-meshheading:20538999-Complement C3,
pubmed-meshheading:20538999-Complement Factor H,
pubmed-meshheading:20538999-Disease Models, Animal,
pubmed-meshheading:20538999-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:20538999-Female,
pubmed-meshheading:20538999-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:20538999-Genotype,
pubmed-meshheading:20538999-Liver,
pubmed-meshheading:20538999-Macular Degeneration,
pubmed-meshheading:20538999-Male,
pubmed-meshheading:20538999-Mice,
pubmed-meshheading:20538999-Mice, Inbred C57BL,
pubmed-meshheading:20538999-Mice, Knockout,
pubmed-meshheading:20538999-Mice, Transgenic,
pubmed-meshheading:20538999-Posterior Eye Segment,
pubmed-meshheading:20538999-RNA, Messenger,
pubmed-meshheading:20538999-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20538999-Risk Factors
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Transgenic mice expressing variants of complement factor H develop AMD-like retinal findings.
|
|
pubmed:affiliation |
Department of Ophthalmology, UT Southwestern Medical Center, Dallas, Texas 75390-9057, USA. rafael.ufret-vincenty@utsouthwestern.edu
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
