Source:http://linkedlifedata.com/resource/pubmed/id/20522617
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0030705,
umls-concept:C0076823,
umls-concept:C0392747,
umls-concept:C0443172,
umls-concept:C0681842,
umls-concept:C0687676,
umls-concept:C0871261,
umls-concept:C0936012,
umls-concept:C1515273,
umls-concept:C1521725,
umls-concept:C1551338,
umls-concept:C1704632,
umls-concept:C1705313,
umls-concept:C1706817,
umls-concept:C2911692
|
| pubmed:issue |
8
|
| pubmed:dateCreated |
2010-7-23
|
| pubmed:abstractText |
Data from 5 atomoxetine trials in pediatric outpatients with attention-deficit/hyperactivity disorder (ADHD) were divided into training and validation data sets to develop models predicting atomoxetine treatment response, using changes in individual ADHD Rating Scale (ADHD-RS) items early in treatment. Treatment response was predicted after 1 week by a > or =1-point score decrease in ADHD-RS item 15 ("easily distracted;" positive predictive values [PPVs]: 84.9%, 74.3%, and 73.3%; negative predictive values [NPVs]: 52.6%, 50.5%, and 46.3%; training and 2 validation data sets, respectively); after 2 to 3 weeks, by a > or =1-point score decrease in ADHD-RS item 1 ("fails to give close attention or makes careless mistakes;" PPV = 77.7% and 77.9%) and by the absence of a > or =1-point score decrease on ADHD-RS items 1 and 10 ("on the go;" NPV = 72.2% and 77.5%), or by the combination of items 1 and 10 (PPVs: 75.1% and 75.4%; NPVs: 72.2% and 77.5%; training and validation data sets, respectively).
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
|
| pubmed:issn |
1938-2707
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
49
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
768-76
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| pubmed:meshHeading |
pubmed-meshheading:20522617-Administration, Oral,
pubmed-meshheading:20522617-Adolescent,
pubmed-meshheading:20522617-Adrenergic Uptake Inhibitors,
pubmed-meshheading:20522617-Attention Deficit Disorder with Hyperactivity,
pubmed-meshheading:20522617-Child,
pubmed-meshheading:20522617-Dose-Response Relationship, Drug,
pubmed-meshheading:20522617-Double-Blind Method,
pubmed-meshheading:20522617-Female,
pubmed-meshheading:20522617-Humans,
pubmed-meshheading:20522617-Male,
pubmed-meshheading:20522617-Outpatients,
pubmed-meshheading:20522617-Pediatrics,
pubmed-meshheading:20522617-Propylamines,
pubmed-meshheading:20522617-Psychological Tests,
pubmed-meshheading:20522617-Reproducibility of Results,
pubmed-meshheading:20522617-Severity of Illness Index,
pubmed-meshheading:20522617-Time Factors,
pubmed-meshheading:20522617-Treatment Outcome
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Post hoc analysis: early changes in ADHD-RS items predict longer term response to atomoxetine in pediatric patients.
|
| pubmed:affiliation |
Kentucky Pediatric Research, Bardstown, KY, USA.
|
| pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|