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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-6-2
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pubmed:abstractText |
Ischemia-reperfusion injury can activate pathways generating reactive oxygen species, which can injure cells by creating holes in the cell membranes. Copolymer surfactants such as poloxamer 188 are capable of sealing defects in cell membranes. The authors postulated that a single-dose administration of poloxamer 188 would decrease skeletal myocyte injury and mortality following ischemia-reperfusion injury.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1529-4242
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
125
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1651-60
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pubmed:dateRevised |
2011-2-16
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pubmed:meshHeading |
pubmed-meshheading:20517088-Adenosine Triphosphate,
pubmed-meshheading:20517088-Animals,
pubmed-meshheading:20517088-Cell Membrane,
pubmed-meshheading:20517088-Dextrans,
pubmed-meshheading:20517088-Disease Models, Animal,
pubmed-meshheading:20517088-Hindlimb,
pubmed-meshheading:20517088-Ischemic Preconditioning,
pubmed-meshheading:20517088-Mice,
pubmed-meshheading:20517088-Mice, Inbred C57BL,
pubmed-meshheading:20517088-Muscle, Skeletal,
pubmed-meshheading:20517088-Poloxamer,
pubmed-meshheading:20517088-Reactive Oxygen Species,
pubmed-meshheading:20517088-Reperfusion Injury,
pubmed-meshheading:20517088-Surface-Active Agents
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pubmed:year |
2010
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pubmed:articleTitle |
Poloxamer 188 protects against ischemia-reperfusion injury in a murine hind-limb model.
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pubmed:affiliation |
Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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