Linked Life Data

20513372

Source:http://linkedlifedata.com/resource/pubmed/id/20513372

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-7-23
pubmed:abstractText
Cholinergic deafferentation of telencephalon is a major factor contributing to cognitive impairment in Alzheimer's disease. There is evidence that the degeneration of cholinergic fibers which innervate the cortex and hippocampus is due to the development of neurofibrillary tangles in the perikarya of origin. Neurofibrillary tangle formation has been modeled in the transgenic pR5 mouse strain that overexpresses the longest human tau isoform together with the P301L mutation that has been previously identified in familial cases of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). To test the suitability of the pR5 model as a model of Alzheimer's disease concerning the cholinergic innervation of the telencephalon, we determined the expression of the human tau transgene and the presence of neurofibrillary changes in the basal nucleus of Meynert, the septal nuclei and the diagonal band of Broca, sources of cholinergic innervation of the cerebral cortex and hippocampus. We found that the cholinergic neurons of these nuclei, despite widespread expression of the human tau transgene, neither expressed human tau nor displayed immunoreactivity with antibodies AT8 and AT180 which recognize hyperphosphorylated tau. Immunoreactivity for choline-acetyl transferase did not reveal significant differences between pR5 mice and non-transgenic littermates in the basal forebrain, cortex and hippocampus. However, in the amygdala dystrophic cholinergic neurites were observed which were not present in non-transgenic mice. Our data show that although pR5 mice develop neurofibrillary lesions, they do not model the degeneration of basal forebrain cholinergic neurons observed in Alzheimer's disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1872-6240
pubmed:author
pubmed:copyrightInfo
Copyright 2010 Elsevier B.V. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
6
pubmed:volume
1347
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
111-24
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Analysis of the cholinergic pathology in the P301L tau transgenic pR5 model of tauopathy.
pubmed:affiliation
Dept. of Anatomy/Neuroanatomy, University Hospital Cologne, Cologne, Germany. c.koehler@uni-koeln.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't