Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2010-5-31
pubmed:abstractText
Cervical tumors of 38 cervix cancer patients were scanned by T(1)-weighted dynamic contrast enhanced (DCE) MRI and then by DCE-CT on the same day. Gadodiamide and iohexol were respectively used as the low-molecular-weight contrast agent in DCE-MRI and DCE-CT. Under an extended Tofts model, DCE-MRI data were analyzed using either individual arterial input functions estimated by a multiple reference tissue method or a population arterial input function by Parker et al., whereas DCE-CT data were analyzed using the arterial input function directly measured from the external iliac arteries. The derived quantitative parameters of cervical tumors were compared between DCE-MRI and DCE-CT. When using the individual multiple reference tissue method arterial input functions to analyze the DCE-MRI data, the correlation coefficients between DCE-MRI- and DCE-CT-derived parameters were, respectively, back-flux rate constant (r = 0.80), extravascular extracellular fractional volume (r = 0.73), contrast agent transfer rate (r = 0.62), and blood plasma volume (r = 0.32); when using the Parker population arterial input function, the correlation coefficients were back-flux rate constant (r = 0.79), extravascular extracellular fractional volume (r = 0.77), contrast agent transfer rate (r = 0.63), and blood plasma volume (r = 0.58). Tumor parametric maps derived by DCE-MRI and DCE-CT had very similar morphologies. However, the means of most derived quantitative parameters were significantly different between the two imaging methods. Close correlation of quantitative parameters derived from two independent imaging modalities suggests both are measuring similar tumor physiologic variables.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-10207488, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-10508281, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-11064398, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-11240971, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-11477267, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-11997530, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-12353256, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-12711641, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-12773666, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-12938136, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-14517187, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-14586998, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-14745444, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-14989624, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-15221817, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-1522275, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-15508148, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-15734934, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-15845797, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-15870830, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-15990015, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-16027440, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-16505397, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-17036301, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-17641369, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-17937595, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-17969061, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-18175123, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-18509724, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-18824708, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-18829475, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-19185002, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-2062210, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-6408018, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-6505043, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-7984064, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-8486503, http://linkedlifedata.com/resource/pubmed/commentcorrection/20512864-9885619
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1522-2594
pubmed:author
pubmed:copyrightInfo
(c) 2010 Wiley-Liss, Inc.
pubmed:issnType
Electronic
pubmed:volume
63
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1601-9
pubmed:dateRevised
2011-7-28
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Comparison of quantitative parameters in cervix cancer measured by dynamic contrast-enhanced MRI and CT.
pubmed:affiliation
Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, Illinois, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't