Source:http://linkedlifedata.com/resource/pubmed/id/20505319
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2010-10-15
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| pubmed:abstractText |
Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality worldwide. MicroRNAs (miRs) are single-stranded, noncoding RNAs that are important in many biological processes. Although the oncogenic and tumor-suppressive functions of several miRs have been characterized, their precise biological roles remain largely unexplored. In the present study, the role of miR-133b was identified in the regulation of CRC cell proliferation and apoptosis. miR-133b expression was shown to be greatly downregulated in human CRC cells compared to normal colon cells. Downregulation of miR-133b expression was also significant in six of eight human CRC tissues compared with adjacent normal tissues. In the CRC cell lines SW-620 and HT-29, ectopic expression of miR-133b potently affected tumor cell proliferation and apoptosis in vitro and in vivo by direct targeting of the receptor tyrosine kinase MET. Transfection of SW-620 and HT-29 cells with miR-133b significantly suppressed a luciferase-reporter containing the MET-3'-untranslated region. Taken together, these results provide evidence that miR-133b regulated tumor cell proliferation and apoptosis through modulation of the MET signaling pathway.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/MET protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MIRN133 microRNA, human,
http://linkedlifedata.com/resource/pubmed/chemical/MicroRNAs,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-met,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Growth Factor
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
1555-8576
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
10
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
190-7
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| pubmed:dateRevised |
2011-3-30
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| pubmed:meshHeading |
pubmed-meshheading:20505319-Analysis of Variance,
pubmed-meshheading:20505319-Animals,
pubmed-meshheading:20505319-Apoptosis,
pubmed-meshheading:20505319-Carcinoma,
pubmed-meshheading:20505319-Cell Line, Tumor,
pubmed-meshheading:20505319-Cell Proliferation,
pubmed-meshheading:20505319-Colorectal Neoplasms,
pubmed-meshheading:20505319-Down-Regulation,
pubmed-meshheading:20505319-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:20505319-Humans,
pubmed-meshheading:20505319-Mice,
pubmed-meshheading:20505319-Mice, Nude,
pubmed-meshheading:20505319-MicroRNAs,
pubmed-meshheading:20505319-Proto-Oncogene Proteins c-met,
pubmed-meshheading:20505319-RNA, Neoplasm,
pubmed-meshheading:20505319-Receptors, Growth Factor,
pubmed-meshheading:20505319-Signal Transduction,
pubmed-meshheading:20505319-Statistics, Nonparametric,
pubmed-meshheading:20505319-Tumor Burden,
pubmed-meshheading:20505319-Tumor Cells, Cultured
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| pubmed:year |
2010
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| pubmed:articleTitle |
miR-133b regulates the MET proto-oncogene and inhibits the growth of colorectal cancer cells in vitro and in vivo.
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| pubmed:affiliation |
Department of General Surgery, The Third Affiliated XiangYa Hospital of Central South University, Changsha, Hunan Province, China.
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| pubmed:publicationType |
Journal Article
|