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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-6-17
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pubmed:abstractText |
VEGF is a well-validated target for antiangiogenic intervention in cancer. To date, RNAi technology has been proven to be a promising approach for targeted therapy. DDP is frequently used as a first-line drug in chemotherapy for lung cancer but usually causes severe toxicity. In this study, we investigated a novel strategy of administering and combining RNAi mediated VEGF-targeted therapy with DDP for treatment of lung cancer, with the aim of increasing efficacy and decreasing toxicity.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20497582-10505043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20497582-10544009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20497582-11001068,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/20497582-12668137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20497582-12778165,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/20497582-9893624
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1756-9966
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pubmed:author |
pubmed-author:ChenXiangX,
pubmed-author:DengHong XHX,
pubmed-author:MaYong PYP,
pubmed-author:VighB JBJ,
pubmed-author:XXX,
pubmed-author:YuJiangJ,
pubmed-author:ZeevH BHB,
pubmed-author:ZhangHouH,
pubmed-author:ZhangNaN,
pubmed-author:ZhangShuangS,
pubmed-author:ZhaoXiaX
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pubmed:issnType |
Electronic
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
56
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pubmed:meshHeading |
pubmed-meshheading:20497582-Adenocarcinoma,
pubmed-meshheading:20497582-Animals,
pubmed-meshheading:20497582-Antineoplastic Agents,
pubmed-meshheading:20497582-Apoptosis,
pubmed-meshheading:20497582-Blotting, Western,
pubmed-meshheading:20497582-Cell Adhesion,
pubmed-meshheading:20497582-Cell Movement,
pubmed-meshheading:20497582-Cell Proliferation,
pubmed-meshheading:20497582-Cisplatin,
pubmed-meshheading:20497582-Combined Modality Therapy,
pubmed-meshheading:20497582-Female,
pubmed-meshheading:20497582-Humans,
pubmed-meshheading:20497582-Immunoenzyme Techniques,
pubmed-meshheading:20497582-Lung Neoplasms,
pubmed-meshheading:20497582-Mice,
pubmed-meshheading:20497582-Mice, Inbred BALB C,
pubmed-meshheading:20497582-Mice, Nude,
pubmed-meshheading:20497582-Plasmids,
pubmed-meshheading:20497582-RNA, Messenger,
pubmed-meshheading:20497582-RNA, Small Interfering,
pubmed-meshheading:20497582-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20497582-Tumor Cells, Cultured,
pubmed-meshheading:20497582-Vascular Endothelial Growth Factors,
pubmed-meshheading:20497582-Xenograft Model Antitumor Assays
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pubmed:year |
2010
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pubmed:articleTitle |
Efficient inhibition of lung cancer in murine model by plasmid-encoding VEGF short hairpin RNA in combination with low-dose DDP.
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pubmed:affiliation |
State Key Laboratory of Biotherapy, West China Hospital and West China Medical School, Sichuan University, Chengdu, Sichuan, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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