Linked Life Data

20491932

Source:http://linkedlifedata.com/resource/pubmed/id/20491932

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2010-8-11
pubmed:abstractText
The vast majority of experimental data have been accumulated on the transcription regulation of individual genes within a single model prokaryote, Escherichia coli, which form the well-established on-off switch model of transcription by DNA-binding regulatory proteins. After the development of modern high-throughput experimental systems such as microarray analysis of whole genome transcription and the Genomic SELEX search for the whole set of regulation targets by transcription factors, a number of E. coli promoters are now recognized to be under the control of multiple transcription factors, as in the case of eukaryotes. The number of regulation targets of a single transcription factor has also been found to be more than hitherto recognized, ranging up to hundreds of promoters, genes or operons for several global regulators. The multifactor promoters and the multitarget transcription factors can be assembled into complex networks of transcription regulation, forming hierarchical networks.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1574-6976
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
628-45
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Prokaryotic genome regulation: multifactor promoters, multitarget regulators and hierarchic networks.
pubmed:affiliation
Department of Frontier Bioscience, Hosei University, Koganei, Tokyo 184-8584, Japan. aishiham@hosei.ac.jp
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't