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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-5-21
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pubmed:abstractText |
There is remarkable controversy over the processes driving abdominal aneurysm growth. The inherent limitations of animal and human studies hamper elucidation of the key inflammatory and proteolytic processes. Human data are largely derived from surgical specimens that typically reflect the final stages of the disease process and thus do not allow distinction between primary and secondary processes. Clear epidemiologic and genetic associations between abdominal aortic aneurysm (AAA) and popliteal artery aneurysms (PAA) suggest that that these two pathologies share common grounds. On this basis, we reasoned that information of corresponding and discordant processes in these aneurysms might provide critical clues on the processes that are crucial for aneurysm progression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1097-6809
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pubmed:author |
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pubmed:copyrightInfo |
Copyright (c) 2010 Society for Vascular Surgery. Published by Mosby, Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1479-87
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pubmed:meshHeading |
pubmed-meshheading:20488324-Aged,
pubmed-meshheading:20488324-Aged, 80 and over,
pubmed-meshheading:20488324-Aneurysm,
pubmed-meshheading:20488324-Aorta, Abdominal,
pubmed-meshheading:20488324-Aortic Aneurysm, Abdominal,
pubmed-meshheading:20488324-Blotting, Western,
pubmed-meshheading:20488324-Cathepsins,
pubmed-meshheading:20488324-Collagenases,
pubmed-meshheading:20488324-Cytokines,
pubmed-meshheading:20488324-Disease Progression,
pubmed-meshheading:20488324-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:20488324-Female,
pubmed-meshheading:20488324-Gene Expression Regulation,
pubmed-meshheading:20488324-Humans,
pubmed-meshheading:20488324-Inflammation Mediators,
pubmed-meshheading:20488324-Macrophages,
pubmed-meshheading:20488324-Male,
pubmed-meshheading:20488324-Middle Aged,
pubmed-meshheading:20488324-NF-kappa B,
pubmed-meshheading:20488324-Neutrophil Infiltration,
pubmed-meshheading:20488324-Popliteal Artery,
pubmed-meshheading:20488324-RNA, Messenger,
pubmed-meshheading:20488324-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20488324-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:20488324-Transcription Factor AP-1
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pubmed:year |
2010
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pubmed:articleTitle |
The pathophysiology of abdominal aortic aneurysm growth: corresponding and discordant inflammatory and proteolytic processes in abdominal aortic and popliteal artery aneurysms.
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pubmed:affiliation |
Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands.
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pubmed:publicationType |
Journal Article,
Comparative Study
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