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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2010-10-28
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pubmed:abstractText |
Somatic cells can be reprogrammed into an embryonic stem cell-like pluripotent state by Oct-3/4, Sox2, c-Myc, and Klf4. Sox2 as an essential reprogramming factor also contributes to the development of the eye and the retina. This study was conducted to determine whether induced pluripotent stem (iPS) cells express retinal progenitor cell (RPC)-related genes and whether iPS cells can directly differentiate into retinal ganglion cells (RGCs).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1552-5783
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pubmed:author |
pubmed-author:ChenMengfeiM,
pubmed-author:ChenQinQ,
pubmed-author:GaoQianyingQ,
pubmed-author:GeJianJ,
pubmed-author:HuangBingB,
pubmed-author:LengYunxiaY,
pubmed-author:LiChunmeiC,
pubmed-author:LiuBingqianB,
pubmed-author:ShenWenjuanW,
pubmed-author:SunXuerongX,
pubmed-author:UonMM,
pubmed-author:XiangAndy PengAP,
pubmed-author:ZhangWeizhongW,
pubmed-author:ZhongXiufengX,
pubmed-author:ZhuoYehongY
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pubmed:issnType |
Electronic
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5970-8
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pubmed:meshHeading |
pubmed-meshheading:20484577-Animals,
pubmed-meshheading:20484577-Biological Markers,
pubmed-meshheading:20484577-Cell Differentiation,
pubmed-meshheading:20484577-Cell Transplantation,
pubmed-meshheading:20484577-Cells, Cultured,
pubmed-meshheading:20484577-Fibroblasts,
pubmed-meshheading:20484577-Flow Cytometry,
pubmed-meshheading:20484577-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:20484577-Gene Expression,
pubmed-meshheading:20484577-Induced Pluripotent Stem Cells,
pubmed-meshheading:20484577-Mice,
pubmed-meshheading:20484577-Mice, Inbred BALB C,
pubmed-meshheading:20484577-Retinal Ganglion Cells,
pubmed-meshheading:20484577-Retroviridae,
pubmed-meshheading:20484577-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20484577-Transcription Factors,
pubmed-meshheading:20484577-Transfection
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pubmed:year |
2010
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pubmed:articleTitle |
Generation of retinal ganglion-like cells from reprogrammed mouse fibroblasts.
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pubmed:affiliation |
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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