Source:http://linkedlifedata.com/resource/pubmed/id/20478304
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
15
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pubmed:dateCreated |
2010-7-26
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pubmed:abstractText |
Plexins serve as receptors for semaphorins and play important roles in the developing nervous system. Plexin-B2 controls decisive developmental programs in the neural tube and cerebellum. However, whether Plexin-B2 also regulates biological functions in adult nonneuronal tissues is unknown. Here we show by two methodologically independent approaches that Plexin-B2 is expressed in discrete cell types of several nonneuronal tissues in the adult mouse. In the vasculature, Plexin-B2 is selectively expressed in functionally specialized endothelial cells. In endocrine organs, Plexin-B2 localizes to the pancreatic islets of Langerhans and to both cortex and medulla of the adrenal gland. Plexin-B2 expression is also detected in certain types of immune and epithelial cells. In addition, we report on a systematic comparison of the expression patterns of Plexin-B2 and its ligand Sema4C, which show complementarity or overlap in some but not all tissues. Furthermore, we demonstrate that Plexin-B2 and its family member Plexin-B1 display largely nonredundant expression patterns. This work establishes Plexin-B2 and Sema4C as potential regulators of the vascular and endocrine system and provides an anatomical basis to understand the biological functions of this ligand-receptor pair.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Plxnb1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Sema4c protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Semaphorins,
http://linkedlifedata.com/resource/pubmed/chemical/beta-Galactosidase,
http://linkedlifedata.com/resource/pubmed/chemical/plexin B2 protein, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1090-2422
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pubmed:author | |
pubmed:copyrightInfo |
Copyright 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
10
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pubmed:volume |
316
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2477-86
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pubmed:meshHeading |
pubmed-meshheading:20478304-Animals,
pubmed-meshheading:20478304-Blood Vessels,
pubmed-meshheading:20478304-Embryo, Mammalian,
pubmed-meshheading:20478304-Endocrine System,
pubmed-meshheading:20478304-Gene Expression Profiling,
pubmed-meshheading:20478304-Gene Expression Regulation, Developmental,
pubmed-meshheading:20478304-Genes, Reporter,
pubmed-meshheading:20478304-Ligands,
pubmed-meshheading:20478304-Mice,
pubmed-meshheading:20478304-Mice, Transgenic,
pubmed-meshheading:20478304-Neovascularization, Physiologic,
pubmed-meshheading:20478304-Nerve Tissue Proteins,
pubmed-meshheading:20478304-Promoter Regions, Genetic,
pubmed-meshheading:20478304-Receptors, Cell Surface,
pubmed-meshheading:20478304-Respiratory System,
pubmed-meshheading:20478304-Semaphorins,
pubmed-meshheading:20478304-beta-Galactosidase
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pubmed:year |
2010
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pubmed:articleTitle |
A systematic expression analysis implicates Plexin-B2 and its ligand Sema4C in the regulation of the vascular and endocrine system.
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pubmed:affiliation |
Max-Planck-Institute for Heart and Lung Research, Department of Pharmacology, Ludwigstr. 43, 61231 Bad Nauheim, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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