Source:http://linkedlifedata.com/resource/pubmed/id/20472983
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2010-5-17
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pubmed:abstractText |
Degeneration of the lumbar spine plays an important role in most chronic low back pain. Prevention of lumbar intervertebral disc (IVD) degeneration is therefore a high research priority. Both our previous multicenter clinical trials and pharmacological research showed that Fufangqishe-Pill (FFQSP), a newly patented traditional Chinese medicine, could effectively relieve the symptoms of neck pain and prevent cervical degeneration. To clarify the effect of FFQSP on lumbar IVD degeneration, we applied a lumbar IVD degeneration rat model induced by prolonged upright posture. Pretreatment of FFQSP for one month prevented the histological changes indicating IVD disorganization; increased type II-collagen level, decreased type X-collagen protein level, and increased Col2alpha1 mRNA expression at all time points; and decreased Col10alpha1, matrix metalloproteinase (MMP)-3, MMP13, and Interleukin (IL)-1beta mRNA expression induced by upright posture for 7 and 9 months. These results suggest that FFQSP prevents lumbar IVD degeneration induced by upright posture. FFQSP is a promising medicine for lumbar IVD degeneration disease.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Actins,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type X,
http://linkedlifedata.com/resource/pubmed/chemical/Drugs, Chinese Herbal,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1beta,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 13,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 3
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pubmed:status |
MEDLINE
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pubmed:issn |
1347-8648
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
113
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
23-31
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20472983-Actins,
pubmed-meshheading:20472983-Animals,
pubmed-meshheading:20472983-Collagen Type II,
pubmed-meshheading:20472983-Collagen Type X,
pubmed-meshheading:20472983-Disease Models, Animal,
pubmed-meshheading:20472983-Drugs, Chinese Herbal,
pubmed-meshheading:20472983-Female,
pubmed-meshheading:20472983-Gene Expression Regulation,
pubmed-meshheading:20472983-Interleukin-1beta,
pubmed-meshheading:20472983-Intervertebral Disc Degeneration,
pubmed-meshheading:20472983-Lumbar Vertebrae,
pubmed-meshheading:20472983-Male,
pubmed-meshheading:20472983-Matrix Metalloproteinase 13,
pubmed-meshheading:20472983-Matrix Metalloproteinase 3,
pubmed-meshheading:20472983-Random Allocation,
pubmed-meshheading:20472983-Rats,
pubmed-meshheading:20472983-Rats, Sprague-Dawley
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pubmed:year |
2010
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pubmed:articleTitle |
Herb formula "Fufangqishe-Pill" prevents upright posture-induced intervertebral disc degeneration at the lumbar in rats.
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pubmed:affiliation |
Department of Orthopaedics & Traumatology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Evaluation Studies
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