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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-5-17
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pubmed:abstractText |
Corticotropin-releasing factor (CRF) plays a central role in regulating stress responses. Forskolin or pituitary adenylate cyclase-activating polypeptide stimulates adenylate cyclase and then increases intracellular cAMP levels in hypothalamic cells. Activation of the protein kinase A pathway leads to binding of cAMP response element (CRE)-binding protein (CREB) on the CRF promoter. Forskolin-stimulated CRF gene transcription is mediated by CRE on the CRF 5'-promoter region. Inducible cAMP-early repressor suppresses a stress response via inhibition of the cAMP-dependent CRF gene. Glucocorticoid-dependent repression of cAMP-stimulated CRF promoter activity is mediated by both nGRE and SRE in hypothalamic cells. Interleukin (IL)-6 produced in the hypothalamus stimulates the CRF gene. Suppressor of cytokine signaling-3, which is induced by a cAMP stimulant and IL-6, is involved in the negative regulation of CRF gene expression in hypothalamic cells. Such complex mechanisms would contribute to stress responses and homeostasis in the hypothalamus.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0083-6729
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Print
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
301-17
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pubmed:meshHeading |
pubmed-meshheading:20472145-Corticotropin-Releasing Hormone,
pubmed-meshheading:20472145-Cyclic AMP Response Element Modulator,
pubmed-meshheading:20472145-Cyclic AMP Response Element-Binding Protein,
pubmed-meshheading:20472145-Estrogens,
pubmed-meshheading:20472145-Gene Expression Regulation,
pubmed-meshheading:20472145-Gene Regulatory Networks,
pubmed-meshheading:20472145-Humans,
pubmed-meshheading:20472145-Hypothalamus,
pubmed-meshheading:20472145-Receptors, Glucocorticoid,
pubmed-meshheading:20472145-Stress, Psychological,
pubmed-meshheading:20472145-Suppressor of Cytokine Signaling Proteins,
pubmed-meshheading:20472145-Transcription Factor AP-1
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pubmed:year |
2010
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pubmed:articleTitle |
Transcriptional regulation of hypothalamic corticotropin-releasing factor gene.
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pubmed:affiliation |
Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan.
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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