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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1991-7-18
|
| pubmed:abstractText |
The Fc-receptor function of the mononuclear phagocyte system (MPS) was examined in 41 children and adult patients, by measuring the clearance of IgG-sensitized, 51Cr-labeled erythrocytes. The Fc-receptor-mediated clearance observed in patients (mean +/- SE) was not significantly different as compared to the control group of similar age distribution. However, the immune clearance time was significantly age-correlated in both groups (acute poststreptococcal glomerulonephritis, APSGN, r = 0.39, p less than 0.05; control r = 0.63, p less than 0.01). The magnitude of the Fc-specific immune clearance and the serum creatinine were also significantly correlated (r = 0.59; p less than 0.01). Circulating immune complexes (as measured by the C1q and conglutinin ELISA) did not correlate with immune clearance, which remained stable in longitudinal studies. Age-related changes in MPS Fc-receptor function could explain, at least in part, prognostic differences between children and adult patients with APSGN.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0028-2766
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
57
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
16-22
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2046809-Adolescent,
pubmed-meshheading:2046809-Adult,
pubmed-meshheading:2046809-Aged,
pubmed-meshheading:2046809-Aging,
pubmed-meshheading:2046809-Child,
pubmed-meshheading:2046809-Chromium Radioisotopes,
pubmed-meshheading:2046809-Creatine,
pubmed-meshheading:2046809-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:2046809-Erythrocytes,
pubmed-meshheading:2046809-Female,
pubmed-meshheading:2046809-Glomerulonephritis,
pubmed-meshheading:2046809-Histocompatibility,
pubmed-meshheading:2046809-Humans,
pubmed-meshheading:2046809-Male,
pubmed-meshheading:2046809-Metabolic Clearance Rate,
pubmed-meshheading:2046809-Middle Aged,
pubmed-meshheading:2046809-Phagocytes,
pubmed-meshheading:2046809-Receptors, Fc,
pubmed-meshheading:2046809-Spleen,
pubmed-meshheading:2046809-Streptococcal Infections
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Age influence on mononuclear phagocyte system Fc-receptor function in poststreptococcal nephritis.
|
| pubmed:affiliation |
Division of Nephrology, School of Medicine, Universidad Austral, Valdivia, Chile.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|