Linked Life Data

2046463

Source:http://linkedlifedata.com/resource/pubmed/id/2046463

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
25
pubmed:dateCreated
1991-7-18
pubmed:abstractText
Interleukins (IL) are naturally occurring proteins that regulate, and thus link, both the immune system and the central nervous system (CNS). Since proteins are assumed not to be able to cross the blood-brain barrier (BBB), it is controversial how this linkage could occur. We show here that after iv injection of 125I-hIL-1 alpha, radioactivity in the brain eluted on HPLC in the position of the labeled cytokine. In addition, entry was inhibited by unlabeled hIL-1 alpha. Our demonstration of a saturable, carrier-mediated system that transports recombinant human IL-1 alpha in intact form from the blood into the CNS indicates a direct immune-CNS connection.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0024-3205
pubmed:author
pubmed:issnType
Print
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
PL117-21
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Blood to brain transport of interleukin links the immune and central nervous systems.
pubmed:affiliation
Department of Veterans Affairs, New Orleans, LA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't