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rdf:type |
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lifeskim:mentions |
umls-concept:C0007613,
umls-concept:C0026639,
umls-concept:C0026809,
umls-concept:C0043240,
umls-concept:C0221928,
umls-concept:C1419227,
umls-concept:C1514873,
umls-concept:C1523351,
umls-concept:C1546857,
umls-concept:C1556066,
umls-concept:C1619636,
umls-concept:C1707937
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pubmed:issue |
5
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pubmed:dateCreated |
2010-5-13
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pubmed:abstractText |
The regenerative capacity of the skin, including the continuous replacement of exfoliated cells and healing of injuries relies on the epidermal stem cells and their immediate cell descendants. The relative contribution of the hair follicle stem cells and the interfollicular stem cells to dermal wound healing is an area of active investigation. Recent studies have revealed that the small GTPase Rac1, which regulates cell migration and nuclear gene expression, is required for hair follicle stem function but not for the normal homeostasis of the interfollicular skin.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-10471461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-11071901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-11825018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-12478284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-12642231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-12810717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-12937137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-14564009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-15024388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-15102710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-15893875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-16081735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-16176279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-16198162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-16288281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-16326396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-16778814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-16943436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-17255473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-17334398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-17389689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-17495958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-18037901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-19022769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-19043850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-1905013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-19387480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-19497277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-19733540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-2430980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-2458356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-6189923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-6201492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-7600581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-8222348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-8689554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-9438836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20463891-9870552
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e10503
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pubmed:dateRevised |
2010-9-28
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pubmed:meshHeading |
pubmed-meshheading:20463891-Animals,
pubmed-meshheading:20463891-Biological Markers,
pubmed-meshheading:20463891-Cell Movement,
pubmed-meshheading:20463891-Cell Proliferation,
pubmed-meshheading:20463891-Dermis,
pubmed-meshheading:20463891-Epidermis,
pubmed-meshheading:20463891-Epithelial Cells,
pubmed-meshheading:20463891-Gene Knockdown Techniques,
pubmed-meshheading:20463891-Homeostasis,
pubmed-meshheading:20463891-Humans,
pubmed-meshheading:20463891-Keratin-6,
pubmed-meshheading:20463891-Keratinocytes,
pubmed-meshheading:20463891-Mice,
pubmed-meshheading:20463891-Mice, Inbred C57BL,
pubmed-meshheading:20463891-Mouth Mucosa,
pubmed-meshheading:20463891-Regeneration,
pubmed-meshheading:20463891-Stem Cells,
pubmed-meshheading:20463891-Tongue,
pubmed-meshheading:20463891-Wound Healing,
pubmed-meshheading:20463891-rac1 GTP-Binding Protein
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pubmed:year |
2010
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pubmed:articleTitle |
Rac1 is required for epithelial stem cell function during dermal and oral mucosal wound healing but not for tissue homeostasis in mice.
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pubmed:affiliation |
Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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