Source:http://linkedlifedata.com/resource/pubmed/id/20458439
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2010-8-4
|
| pubmed:abstractText |
Cardiovascular events are more frequent in high-risk coronary artery disease (CAD) patients on dual antiplatelet therapy with a residual platelet reactivity (RPR) than in those showing inhibition of ADP-inducible platelet activation. It is known that post-interventional RPR is a clinically important entity confirming it as a risk factor for thrombo-ischaemic events. Multiple electrode platelet aggregometry (MEA) on whole blood has been recently proposed as a rapid tool to evaluate RPR in high-risk CAD patients on clopidogrel therapy. It was the aim of this study to detect RPR in 801 high-risk CAD patients on dual antiplatelet therapy comparing MEA with the VerifyNow P2Y12 assay on whole blood and classical light transmission aggregation (LTA) on platelet-rich plasma. ADP (10 microM) was employed as agonist for MEA and LTA. The prevalence of RPR was 20.6% by MEA, 16.1% by LTA and 30.8% by VerifyNow. MEA showed a significant correlation (rho=0.62, p<0.0001) with VerifyNow and a moderate agreement (k=0.52, p<0.001) with 81.5% of concordant values. A significant correlation was found between MEA and LTA (rho=0.71, p<0.001) with a good agreement (k=0.63, p<0.001) and 88.8% of concordant values. MEA in relation to LTA showed a sensitivity of 80% and a specificity of 91%. MEA might represent a reliable method and valid alternative in comparison with other available platelet function assays. It might help to guide antiplatelet therapy and thus improve clinical outcome of high-risk CAD patients.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Diphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/P2RY12 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet Aggregation Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Purinergic P2Y12
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0340-6245
|
| pubmed:author |
pubmed-author:AbbateRosannaR,
pubmed-author:AntonucciEmiliaE,
pubmed-author:BalziDanielaD,
pubmed-author:GiustiBettiB,
pubmed-author:GoriAnna MariaAM,
pubmed-author:MagginiNiccolòN,
pubmed-author:MarcucciRossellaR,
pubmed-author:MirandaMarcoM,
pubmed-author:PanicciaRitaR,
pubmed-author:PriscoDomenicoD
|
| pubmed:issnType |
Print
|
| pubmed:volume |
104
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
287-92
|
| pubmed:dateRevised |
2011-5-23
|
| pubmed:meshHeading |
pubmed-meshheading:20458439-Adenosine Diphosphate,
pubmed-meshheading:20458439-Aged,
pubmed-meshheading:20458439-Aged, 80 and over,
pubmed-meshheading:20458439-Angioplasty, Balloon, Coronary,
pubmed-meshheading:20458439-Blood Platelets,
pubmed-meshheading:20458439-Coronary Artery Disease,
pubmed-meshheading:20458439-Drug Monitoring,
pubmed-meshheading:20458439-Female,
pubmed-meshheading:20458439-Humans,
pubmed-meshheading:20458439-Italy,
pubmed-meshheading:20458439-Male,
pubmed-meshheading:20458439-Middle Aged,
pubmed-meshheading:20458439-Platelet Aggregation,
pubmed-meshheading:20458439-Platelet Aggregation Inhibitors,
pubmed-meshheading:20458439-Platelet Function Tests,
pubmed-meshheading:20458439-Point-of-Care Systems,
pubmed-meshheading:20458439-Predictive Value of Tests,
pubmed-meshheading:20458439-Receptors, Purinergic P2Y12,
pubmed-meshheading:20458439-Registries,
pubmed-meshheading:20458439-Reproducibility of Results,
pubmed-meshheading:20458439-Risk Assessment,
pubmed-meshheading:20458439-Risk Factors,
pubmed-meshheading:20458439-Stents,
pubmed-meshheading:20458439-Thrombosis,
pubmed-meshheading:20458439-Treatment Outcome
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Comparison of methods for monitoring residual platelet reactivity after clopidogrel by point-of-care tests on whole blood in high-risk patients.
|
| pubmed:affiliation |
Department of Medical and Surgical Critical Care, Thrombosis Center, University of Florence, Florence, Italy. rita.paniccia@unifi.it
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|