20450282

Source:http://linkedlifedata.com/resource/pubmed/id/20450282

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0003261, umls-concept:C0542341, umls-concept:C0599921
pubmed:issue	4-5
pubmed:dateCreated	2010-5-10
pubmed:abstractText	Abundant evidence supports the notion that human intestinal plasma cells are largely derived from B cells initially activated in gut-associated lymphoid tissue (GALT). Nevertheless, insufficient knowledge exists about the uptake, processing, and presentation of luminal antigens occurring in GALT to accomplish priming and sustained expansion of mucosal B cells. Also, it is unclear how the germinal center reaction so strikingly promotes class switch to IgA and expression of J chain, although the commensal microbiota appears to contribute to both diversification and memory. B-cell migration from GALT to the intestinal lamina propria is guided by rather well-defined adhesion molecules and chemokines/chemokine receptors, but the cues directing homing to secretory effector sites beyond the gut require better definition. In this respect, the role of human Waldeyer's ring (including adenoids and the palatine tonsils) as a regional mucosa-associated lymphoid tissue must be better defined, although the balance of evidence suggests that it functions as nasopharynx-associated lymphoid tissue (NALT) like the characteristic NALT structures in rodents. Altogether, data suggest a remarkable compartmentalization of the mucosal immune system that must be taken into account in the development of effective local vaccines to protect specifically the airways, small and large intestines, and the female genital tract.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/20450282
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8504629
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:issn	1532-4311
pubmed:author	pubmed-author:BrandtzaegPerP
pubmed:issnType	Electronic
pubmed:volume	39
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	303-55
pubmed:dateRevised	2010-9-23
pubmed:meshHeading	pubmed-meshheading:20450282-Animals, pubmed-meshheading:20450282-Antibody Formation, pubmed-meshheading:20450282-B-Lymphocytes, pubmed-meshheading:20450282-Humans, pubmed-meshheading:20450282-Immunity, Mucosal, pubmed-meshheading:20450282-Lymphoid Tissue, pubmed-meshheading:20450282-Mucous Membrane
pubmed:year	2010
pubmed:articleTitle	Function of mucosa-associated lymphoid tissue in antibody formation.
pubmed:affiliation	Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), Centre for Immune Regulation, University of Oslo, Department and Institute of Pathology, Oslo University Hospital, Rikshospitalet, N-0027 Oslo, Norway. per.brandtzaeg@medisin.uio.no
pubmed:publicationType	Journal Article, Review, Research Support, Non-U.S. Gov't