Linked Life Data

20449848

Source:http://linkedlifedata.com/resource/pubmed/id/20449848

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2010-5-25
pubmed:abstractText
The synthesis of 1,18-nucleotide-appended bolaamphiphiles (1, 2, 4, and 6) is reported, in which a 3'-phosphorylated guanidine, adenosine, thymidine, or cytidine is connected to each end of an octadecamethylene chain. Single-component self-assemblies and binary self-assemblies with the complementary oligonucleotides dC(20), dT(20), dA(20), and dG(20) are studied by atomic force microscopy, powder X-ray diffraction analysis, temperature-dependent UV absorption, circular dichroism, and attenuated total-reflection Fourier-transform infrared spectroscopy. The single-component self-assembly of 1 forms a two-dimensional sheet, whereas the binary self-assembly 1/dC(20) gives helical nanofibers. Non-helical nanofibers are observed for the single-component self-assemblies of 2 and 4, and helical nanofibers form from the binary self-assembly 2/dT(20). Interestingly, helical nanorod structures are obtained from the binary self-assembly 4/dA(20), and the aligned nanorods form a nematic phase. The single-component and binary self-assemblies from 6 give unilamellar vesicles owing to a lack of stacking interaction between the cytosine moieties.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1613-6829
pubmed:author
pubmed:issnType
Electronic
pubmed:day
21
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1131-9
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Diverse morphologies of self-assemblies from homoditopic 1,18-nucleotide-appended bolaamphiphiles: effects of nucleobases and complementary oligonucleotides.
pubmed:affiliation
National Food Research Institute National Agriculture and Food Research Organization, 2-1-12 Kannondai, Tsukuba, Ibaraki, 305-8642, Japan. riwaura@affrc.go.jp
pubmed:publicationType
Journal Article