|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2010-5-6
|
|
pubmed:abstractText |
The role of beta-receptor selectivity for the interaction between the angiotensin-converting enzyme (ACE) insertion/deletion polymorphism and beta-blocker therapy was investigated in 479 subjects with left ventricular dysfunction. Subjects were separated into no beta-blocker, beta1 -selective, and nonselective beta-blocker treatment groups. The D allele adversely affected transplant-free survival for subjects not on beta-blockers (p= 0.004). Treatment with selective beta1-blockers eliminated the impact of the D allele (p= 0.51) in a manner similar to nonselective beta1,2-blockers (p= 0.80). Treatment with beta1-blockers was sufficient to eliminate the adverse impact of the ACE D allele, suggesting this pharmacogenetic interaction is mediated through the beta1-receptor.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
1752-8062
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
1
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
151-4
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:20443839-Adrenergic beta-1 Receptor Antagonists,
pubmed-meshheading:20443839-Adrenergic beta-Antagonists,
pubmed-meshheading:20443839-Alleles,
pubmed-meshheading:20443839-Cohort Studies,
pubmed-meshheading:20443839-Demography,
pubmed-meshheading:20443839-Disease-Free Survival,
pubmed-meshheading:20443839-Female,
pubmed-meshheading:20443839-Genotype,
pubmed-meshheading:20443839-Humans,
pubmed-meshheading:20443839-INDEL Mutation,
pubmed-meshheading:20443839-Male,
pubmed-meshheading:20443839-Middle Aged,
pubmed-meshheading:20443839-Peptidyl-Dipeptidase A,
pubmed-meshheading:20443839-Pharmacogenetics,
pubmed-meshheading:20443839-Receptors, Adrenergic, beta-1
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
The beta1-adrenergic receptor mediates the pharmacogenetic interaction of the ACE D allele and beta-blockers.
|
|
pubmed:affiliation |
Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|
