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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2010-9-23
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pubmed:abstractText |
Small-cell lung cancer (SCLC) carries the worst prognosis among lung cancer diagnoses. Combined radiation and chemotherapy is the standard of care; however, treatment outcomes vary. Variability in the rate at which chemotherapy agents are metabolized and in the capacity of repairing DNA damage has been hypothesized to be partly responsible for the treatment response variation. Genes in the glutathione metabolism and DNA repair pathways were tested through tag single-nucleotide polymorphisms (SNPs) to assess their association with survival in SCLC.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1569-8041
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pubmed:author |
pubmed-author:AakreJJ,
pubmed-author:ChenJJ,
pubmed-author:CunninghamJ MJM,
pubmed-author:GarcesY YYY,
pubmed-author:IdowuOO,
pubmed-author:JiangRR,
pubmed-author:LieII,
pubmed-author:MarksR SRS,
pubmed-author:PankratzV SVS,
pubmed-author:SunZZ,
pubmed-author:YangPP
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pubmed:issnType |
Electronic
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2011-6
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pubmed:dateRevised |
2011-10-3
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pubmed:meshHeading |
pubmed-meshheading:20439344-Aged,
pubmed-meshheading:20439344-DNA Repair,
pubmed-meshheading:20439344-DNA-Binding Proteins,
pubmed-meshheading:20439344-Female,
pubmed-meshheading:20439344-Genotype,
pubmed-meshheading:20439344-Glutathione,
pubmed-meshheading:20439344-Haplotypes,
pubmed-meshheading:20439344-Humans,
pubmed-meshheading:20439344-Lung Neoplasms,
pubmed-meshheading:20439344-Male,
pubmed-meshheading:20439344-Middle Aged,
pubmed-meshheading:20439344-Multidrug Resistance-Associated Proteins,
pubmed-meshheading:20439344-Polymorphism, Single Nucleotide,
pubmed-meshheading:20439344-Prognosis,
pubmed-meshheading:20439344-Small Cell Lung Carcinoma,
pubmed-meshheading:20439344-Survival Rate,
pubmed-meshheading:20439344-Tumor Markers, Biological
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pubmed:year |
2010
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pubmed:articleTitle |
Genetic variation in glutathione metabolism and DNA repair genes predicts survival of small-cell lung cancer patients.
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pubmed:affiliation |
Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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