|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0022417,
umls-concept:C0052441,
umls-concept:C0086045,
umls-concept:C0205246,
umls-concept:C0243076,
umls-concept:C0243192,
umls-concept:C0679932,
umls-concept:C0681842,
umls-concept:C0728938,
umls-concept:C1280500,
umls-concept:C1883712
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2010-5-3
|
|
pubmed:abstractText |
Predicting the expected outcome of a combination exposure is critical to risk -assessment. The toxic equivalency factor (TEF) approach used for analyzing joint effects of dioxin-like chemicals is a special case of the method of concentration addition. However, the TEF method assumes that individual agents are full aryl hydrocarbon receptor (AhR) agonists with parallel dose-response curves, whereas many mixtures include partial agonists.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20435555-10188874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20435555-11032772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20435555-11812924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20435555-11993873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20435555-12213382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20435555-14560034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20435555-14736496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20435555-16750337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20435555-16829543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20435555-18174957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20435555-19345693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20435555-2692037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20435555-7589923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20435555-8748700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20435555-8806883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20435555-8975631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20435555-9508738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20435555-9703492
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
1552-9924
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
118
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
666-72
|
|
pubmed:dateRevised |
2010-9-28
|
|
pubmed:meshHeading |
pubmed-meshheading:20435555-Animals,
pubmed-meshheading:20435555-Binding, Competitive,
pubmed-meshheading:20435555-Cell Line,
pubmed-meshheading:20435555-Dose-Response Relationship, Drug,
pubmed-meshheading:20435555-Environmental Exposure,
pubmed-meshheading:20435555-Environmental Pollutants,
pubmed-meshheading:20435555-Humans,
pubmed-meshheading:20435555-Kinetics,
pubmed-meshheading:20435555-Ligands,
pubmed-meshheading:20435555-Mice,
pubmed-meshheading:20435555-Models, Biological,
pubmed-meshheading:20435555-Polychlorinated Biphenyls,
pubmed-meshheading:20435555-Receptors, Aryl Hydrocarbon,
pubmed-meshheading:20435555-Risk Assessment
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Generalized concentration addition predicts joint effects of aryl hydrocarbon receptor agonists with partial agonists and competitive antagonists.
|
|
pubmed:affiliation |
Environmental Health Department, Boston University School of Public Health, Boston, Massachusetts 02118 , USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
|
