|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2011-2-7
|
|
pubmed:abstractText |
Previously, we demonstrated that inhibition of poly(ADP-ribose) polymerase (PARP) exerts protective effects against high-fat (HF) diet-induced atherogenesis in part by increasing tissue inhibitor of metalloproteinase (TIMP)-2 expression. Given that characteristics of dilated cardiomyopathy closely associate with atherosclerosis and are mediated by an imbalance between matrix metalloproteinases (MMPs) and TIMPs, we hypothesized that PARP-1 gene deletion may protect against HF-induced cardiac hypertrophy and dilatations by altering TIMP-2/MMPs balance in favor of a maintenance of tissue homeostasis.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1879-1336
|
|
pubmed:author |
pubmed-author:BoularesA HamidAH,
pubmed-author:FengYumeiY,
pubmed-author:HansChetan PCP,
pubmed-author:JuJihangJ,
pubmed-author:KayeAlan DAD,
pubmed-author:KimHogyoungH,
pubmed-author:LazartiguesEricE,
pubmed-author:MatrouguiKhalidK,
pubmed-author:NauraAmarjit SAS,
pubmed-author:SiddiquiDanishD,
pubmed-author:TroxclairDanaD,
pubmed-author:ZerfaouiMouradM
|
|
pubmed:copyrightInfo |
Copyright © 2011 Elsevier Inc. All rights reserved.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
20
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
e57-68
|
|
pubmed:dateRevised |
2011-9-26
|
|
pubmed:meshHeading |
pubmed-meshheading:20434371-Animals,
pubmed-meshheading:20434371-Apoptosis,
pubmed-meshheading:20434371-Blotting, Western,
pubmed-meshheading:20434371-Cardiomyopathy, Dilated,
pubmed-meshheading:20434371-Cell Degranulation,
pubmed-meshheading:20434371-Diet, Atherogenic,
pubmed-meshheading:20434371-Dyslipidemias,
pubmed-meshheading:20434371-Immunohistochemistry,
pubmed-meshheading:20434371-In Situ Nick-End Labeling,
pubmed-meshheading:20434371-Mast Cells,
pubmed-meshheading:20434371-Matrix Metalloproteinase 9,
pubmed-meshheading:20434371-Mice,
pubmed-meshheading:20434371-Mice, Inbred C57BL,
pubmed-meshheading:20434371-Mice, Knockout,
pubmed-meshheading:20434371-Poly(ADP-ribose) Polymerases,
pubmed-meshheading:20434371-Polymerase Chain Reaction,
pubmed-meshheading:20434371-Tissue Inhibitor of Metalloproteinase-2,
pubmed-meshheading:20434371-Transfection
|
|
pubmed:articleTitle |
Opposing roles of PARP-1 in MMP-9 and TIMP-2 expression and mast cell degranulation in dyslipidemic dilated cardiomyopathy.
|
|
pubmed:affiliation |
Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA, USA. chetan.hans@nationwidechildrens.org
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
